Results 51 to 60 of about 392,840 (275)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

A perturbative solution to metadynamics ordinary differential equation

, 2015
Metadynamics is a popular enhanced sampling scheme wherein by periodic application of a repulsive bias, one can surmount high free energy barriers and explore complex landscapes.
Dama, James F., Parrinello, Michele, Tiwary, Pratyush   +2 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Population Growth Models Using Fuzzy Ordinary Differential Equation

Semina: Ciências Exatas e Tecnológicas
Fuzzy mathematics is a branch of mathematics that presents a new approach to the classical notion of set, enabling the generalization of concepts and results from classical mathematics.
Diogo Sampaio da Silva, Roberto Antonio Cordeiro Prata   +1 more
doaj   +1 more source

On Nonlinear Dynamics of the STAT5a Signaling Protein

Biomath, 2014
In this paper we model the dynamics of the cross talk between MEK/ERK and JAK/STAT signaling pathways by means of nonlinear ordinary differential equations.
Elena Nikolova, Ivan Jordanov, Nikolay K. Vitanov   +2 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Similarity solutions of Fokker-Planck equation with time-dependent coefficients

, 2011
In this work, we consider the solvability of the Fokker-Planck equation with both time-dependent drift and diffusion coefficients by means of the similarity method.
Bluman, C.-L. Ho, Caroli, Drozdov, Fa, González, Gunaratne, Gunaratne, Ho, Ho, Lillo, Lin, Owedyk, Risken, Spichak, Turbiner, Turbiner, Ushveridze, W.-T. Lin, Weidlich, Zienkiewicz, Zwillinger   +21 more
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Numerical Solution of Stieltjes Differential Equations

Mathematics, 2020
This work is devoted to the obtaining of a new numerical scheme based on quadrature formulae for the Lebesgue–Stieltjes integral for the approximation of Stieltjes ordinary differential equations.
Francisco J. Fernández, F. Adrián F. Tojo   +1 more
doaj   +1 more source

Motion Planning of Uncertain Ordinary Differential Equation Systems [PDF]

, 2011
This work presents a novel motion planning framework, rooted in nonlinear programming theory, that treats uncertain fully and under-actuated dynamical systems described by ordinary differential equations.
Hays, Joe, Hong, Dennis, Sandu, Adrian, Sandu, Corina   +3 more
core   +1 more source