Results 121 to 130 of about 94,059 (356)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

On bounded solutions of differential systems

open access: yesВестник КазНУ. Серия математика, механика, информатика, 2022
The question of the existence of bounded solutions on an infinite interval of a linear inhomogeneous system of ordinary differential equations in a finite-dimensional space is considered. The study of bounded solutions of systems of ordinary differential
T. M. Aldibekov
doaj  

Genetic programming approaches for solving elliptic partial differential equations

open access: yes, 2008
In this paper, we propose a technique based on genetic programming (GP) for meshfree solution of elliptic partial differential equations. We employ the least-squares collocation principle to define an appropriate objective function, which is optimized ...
Sobester, A.   +5 more
core   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

open access: yesFEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee   +3 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Strong monotonicity for analytic ordinary differential equations

open access: yesElectronic Journal of Differential Equations, 2009
We present a necessary and sufficient criterion for the flow of an analytic ordinary differential equation to be strongly monotone; equivalently, strongly order-preserving.
Sebastian Walcher, Christian Zanders
doaj  

Exploring novel applications of stochastic differential equations: Unraveling dynamics in plasma physics with the Tanh-Coth method

open access: yesResults in Physics
This study addresses the solution of differential equations converted into stochastic differential equations with the introduction of a noise term. To simplify the stochastic complexity, we employ a transformation, converting the equations into ordinary ...
Jamil Abbas Haider   +2 more
doaj   +1 more source

Higher-order finite-difference methods for partial differential equations

open access: yes, 1997
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.This thesis develops two families of numerical methods, based upon rational approximations having distinct real poles, for solving first- and second-order ...
Cheema, Tasleem Akhter, Cheema, T.A.
core  

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

open access: yesFEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata   +13 more
wiley   +1 more source

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