Results 61 to 70 of about 94,059 (356)

Oscillatory bifurcation for semilinear ordinary differential equations

Electronic Journal of Qualitative Theory of Differential Equations, 2016
We consider the nonlinear eigenvalue problem \[u''(t) + \lambda f(u(t)) = 0, \quad u(t) > 0, \quad t \in I := (-1,1), \quad u(1) = u(-1) = 0, \] where $f(u) = u + (1/2)\sin^k u$ ($k \ge 2$) and $\lambda > 0$ is a bifurcation parameter.
Tetsutaro Shibata
doaj   +1 more source

Numerical Solution of Stieltjes Differential Equations

Mathematics, 2020
This work is devoted to the obtaining of a new numerical scheme based on quadrature formulae for the Lebesgue–Stieltjes integral for the approximation of Stieltjes ordinary differential equations.
Francisco J. Fernández, F. Adrián F. Tojo   +1 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

On exponential stability of functional differential equations with variable impulse perturbations

, 2014
We consider a class of functional differential equations subject to perturbations, which vary in time, and we study the exponential stability of solutions of these equations using the theory of generalized ordinary differential equations and Lyapunov ...
Bonotto, Everaldo de Mello, Federson, Márcia Cristina Anderson Braz, Afonso, S. M.   +2 more
core   +4 more sources

Green's Function Method for Ordinary Differential Equations

مجلة المختار للعلوم, 2013
The analytical solution of non homogeneous boundary value problem in the form: Lyx=fx          axb                              B1ya=0                               B2yb=0 are obtained by using Green's function method.
Fouad A Zein Elarab, Abdassalam B Aldaikh   +1 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Almost sure exponential stability of numerical solutions for stochastic delay differential equations

, 2010
Using techniques based on the continuous and discrete semimartingale convergence theorems, this paper investigates if numerical methods may reproduce the almost sure exponential stability of the exact solutions to stochastic delay differential equations (
Szpruch, Lukasz, Wu, Fuke, Mao, Xuerong
core   +1 more source

Perturbation of domain: ordinary differential equations [PDF]

Proceedings of the Royal Society of Edinburgh: Section A Mathematics, 2002
We study a boundary perturbation problem for a one-dimensional Schrödinger equation in which the potential has a regular singularity near the perturbed end point. We give the asymptotic behaviour of the eigenvalues under the perturbation. This problem arose out of the author's studies of singular elliptic operators in higher dimensions and we ...
openaire   +3 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source