Results 81 to 90 of about 2,763,547 (281)

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

The Finite Element Method for Stiff Ordinary Differential Equations

AppliedMath
The paper utilizes the continuous finite element method to solve stiff ordinary differential equations and proves that the linear finite element method and the quadratic finite element method have A-stability in solving autonomous ordinary differential ...
Yanhui Ding, Qiong Tang, Sijia Tang
doaj   +1 more source

Doubly Periodic Meromorphic Solutions of Autonomous Nonlinear Differential Equations

Моделирование и анализ информационных систем, 2014
The problem of constructing and classifying elliptic solutions of nonlinear differential equations is studied. An effective method enabling one to find an elliptic solution of an autonomous nonlinear ordinary differential equation is described.
M. V. Demina, N. A. Kudryashov
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Geometric Linearization of Ordinary Differential Equations

Symmetry, Integrability and Geometry: Methods and Applications, 2007
The linearizability of differential equations was first considered by Lie for scalar second order semi-linear ordinary differential equations. Since then there has been considerable work done on the algebraic classification of linearizable equations and ...
Asghar Qadir
doaj  

From MIN model to ordinary differential equations

Journal of Integrative Bioinformatics, 2007
Biological interaction networks can be modeled using the Modular Interaction Network (MIN) formalism, which provides an intermediary modeling level between the biological and mathematical ones.
Yartseva A., Devillers R., Klaudel H., Képès F.   +3 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Measure functional differential equations and functional dynamic equations on time scales

, 2012
We study measure functional differential equations and clarify their relation to generalized ordinary differential equations. We show that functional dynamic equations on time scales represent a special case of measure functional differential equations ...
Mesquita, Jaqueline Godoy, Slavik, Antonin, Federson, Márcia Cristina Anderson Braz, Márcia Federson, Jaqueline G. Mesquita, Antonín Slavík   +5 more
core   +1 more source

A new type of integral transform and its applications to the solution of differential equations

Boundary Value Problems
In this paper, we introduce a novel integral transform to address certain ordinary differential equations, and it has been demonstrated that this transform possesses unique and highly advantageous properties.
Mohamed Elarbi Benattia, Khellaf Ould Melha, Vaijanath L. Chinchane, Asha B. Nale, Sabri T. M. Thabet, Imed Kedim   +5 more
doaj   +1 more source