Results 81 to 90 of about 385,390 (280)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

A new type of integral transform and its applications to the solution of differential equations

Boundary Value Problems
In this paper, we introduce a novel integral transform to address certain ordinary differential equations, and it has been demonstrated that this transform possesses unique and highly advantageous properties.
Mohamed Elarbi Benattia, Khellaf Ould Melha, Vaijanath L. Chinchane, Asha B. Nale, Sabri T. M. Thabet, Imed Kedim   +5 more
doaj   +1 more source

Side conditions for ordinary differential equations

, 2014
We specialize Olver's and Rosenau's side condition heuristics for the determination of particular invariant sets of ordinary differential equations. It turns out that side conditions of so-called LaSalle type are of special interest. Moreover we put side
Cicogna, G., Gaeta, G., Walcher, S.
core  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Cauchy-Kowalevski and polynomial ordinary differential equations

Electronic Journal of Differential Equations, 2012
The Cauchy-Kowalevski Theorem is the foremost result guaranteeing existence and uniqueness of local solutions for analytic quasilinear partial differential equations with Cauchy initial data. The techniques of Cauchy-Kowalevski may also be applied to
Roger J. Thelwell, Paul G. Warne, Debra A. Warne   +2 more
doaj  

Four Steps Implicit Method for the Solution of General Second Order Ordinary Differential Equations [PDF]

, 2009
Four steps implicit scheme for the solution of second order ordinary differential equation was derived through interpolation and collocation method. Newton polynomial approximation method was used to generate the unknown parameters in the corrector ...
Adesanya, A.O., Anake, T. A., Oghonyon, J. G., Osilagun, J.A.   +3 more
core  

Symmetries and reductions of integrable nonlocal partial differential equations

, 2019
In this paper, symmetry analysis is extended to study nonlocal differential equations, in particular two integrable nonlocal equations, the nonlocal nonlinear Schr\"odinger equation and the nonlocal modified Korteweg--de Vries equation.
Peng, Linyu
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source