Results 121 to 130 of about 25,394 (231)

A repeat expansion in GOLGA8A is a major risk factor for atypical frontotemporal lobar degeneration with ubiquitin-positive inclusions. [PDF]

Nat Genet
De Coster W, Van den Broeck M, Baker M, Ghayal NB, Wynants S, Batzler A, Pottier C, Alidadiani S, Küçükali F, Jenkins GD, Policarpo R, van Blitterswijk M, DeJesus-Hernandez M, Soto-Beasley AI, Faura J, Coopman E, Hutten S, Mol MO, Wallon D, Sieben A, Finger EC, Murray ME, Forrest SL, Tartaglia MC, Troakes C, van Rooij JGJ, Nguyen AT, Reichard RR, Woodman NL, Nana AL, Weintraub S, Gefen T, De Vil B, Bodi I, Lopez OL, Boluda S, Belliard S, Lebert F, Marguet F, Mao Q, Mesulam MM, Boxer AL, Vandenbulcke M, Suh E, Schaeverbeke J, Lambert JC, Scholz SW, Dalgard CL, Traynor BJ, Gibbs RJ, Schellenberg GD, Dormann D, Joris G, De Pooter T, De Rijk P, D'Hert S, Van Dongen J, van der Zee J, Strazisar M, Gearing M, Kukar T, Flanagan M, Engelborghs S, Ghetti B, Newell KL, King A, Roeber S, Rosen HJ, Spina S, Cras P, Ertekin-Taner N, Wszolek ZK, Uitti RJ, Cheshire WP, Singer W, Herms J, Josephs KA, Whitwell JL, Petersen RC, Pasquier F, Nicolas G, Castellani R, Glass J, Miller BL, Kovacs GG, Rissman RA, Hiniker A, Deramecourt V, Ang LC, Lee-Way J, Van Deerlin VM, Dugger BN, Thal DR, Grinberg LT, Cruchaga C, Arzberger T, Munoz DG, Keith J, Zinman L, Rogaeva E, Lee EB, Haggarty SJ, Ansorge O, Husain M, Halliday GM, Al-Sarraj S, Ross OA, Sleegers K, Vandenberghe R, Boeve BF, Graff-Radford NR, Kofler J, White CL, Lashley T, Neumann M, Biernacka JM, Seeley WW, Seelaar H, van Swieten JC, Rohrer JD, Dickson DW, Mackenzie IRA, Rademakers R.   +122 more
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Solutions of a Class of Switch Dynamical Systems. [PDF]

Entropy (Basel)
Danca MF.
europepmc   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Distinct impacts of human co-chaperone UNC45 paralogs on Drosophila muscle development and function. [PDF]

J Cell Sci
Smith DA, Mullens MI, Ramos R, Melkani GC, Bernstein SI.   +4 more
europepmc   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Tri-snRNP activity modulates tauopathy phenotypes. [PDF]

NAR Mol Med
LeBlanc KR, Eck RJ, Saxton AD, McMillan PJ, Wheeler JM, Liachko NF, Keene CD, Latimer CS, Kow RL, Kraemer BC.   +9 more
europepmc   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Structure and ultrastructure of nuptial and extranuptial nectaries explain secretion changes throughout flower lifetime and allow for multiple ecological interactions. [PDF]

AoB Plants
Balduino H, Tunes P, Nepi M, Guimarães E, Machado SR.   +4 more
europepmc   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source