Results 41 to 50 of about 1,781 (243)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Periodic solutions of linear impulsive differential inclusions

open access: yes, 2004
Для лiнiйних диференцiальних включень iз iмпульсами у фiксованi моменти часу встановлено умови iснування перiодичних звичайних розв’язкiв i R-розв’язкiв.For linear differential inclusions with impulsive effects at fixed moments, we find conditions for ...
Плотникова, Н.В.
core   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Geometric Characterization of Validity of the Lyapunov Convexity Theorem in the Plane for Two Controls under a Pointwise State Constraint

open access: yesAxioms
This paper concerns control BVPs, driven by ODEs x′t=ut, using controls u0· &u1· in L1a,b,R2. We ask these two controls to satisfy a very simple restriction: at points where their first coordinates coincide, also their second coordinates must coincide ...
Clara Carlota   +2 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Bifurcation from Homoclinic to Periodic Solutions in Ordinary Differential Equations with Multivalued Perturbations

open access: yes, 1996
The existence of periodic solutions are studied for certain differential inclusions. Applications are given to ordinary differential equations with multivalued perturbations embodying also dry friction problems.
Fečkan, Michal
core   +1 more source

Three periodic solutions for an ordinary differential inclusion with two parameters

open access: yesAnnales Polonici Mathematici, 2012
Applying a nonsmooth version of a three critical points theorem of Ricceri, we prove the existence of three periodic solutions for an ordinary differential inclusion depending on two parameters.
openaire   +3 more sources

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Quadratic stability of non-linear systems modeled with norm bounded linear differential inclusions

open access: yes, 2020
In this article we present an ordinary differential equation based technique to study the quadratic stability of non-linear dynamical systems. The non-linear dynamical systems are modeled with norm bounded linear differential inclusions.
Arfan Hyder   +5 more
core   +1 more source

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