Results 51 to 60 of about 25,394 (231)

Effective conductivity of composites of graded spherical particles

, 2005
We have employed the first-principles approach to compute the effective response of composites of graded spherical particles of arbitrary conductivity profiles. We solve the boundary-value problem for the polarizability of the graded particles and obtain
Arnold, Bollenbach, Chan, Dong, Dong, Fuhr, G.Q. Gu, Gu, Gu, Gu, Holt, Huang, Huang, Hughes, Ilschner, Jackson, K.W. Yu, Larson, Lin, Martin, Milton, Snyder, Wei, Yu, Yu   +24 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Existence theorems for nth-order discontinuous ordinary differential inclusions

Applied Mathematics Letters, 2006
The author studies the following problem for an \(n\)th-order differential inclusion: \[ \begin{cases} x^{(n)}(t) \in F(t,x(t)) & \text{for a.e. } t\in J,\\ x^{(i)}(0)=x_i\in \mathbb R, & i\in \{1,\dots,n-1\}, \end{cases} \] where \(J=[0,T]\) and \(F:J \times \mathbb R\to 2^{\mathbb R}\) is a multifunction.
openaire   +3 more sources

Geometric Characterization of Validity of the Lyapunov Convexity Theorem in the Plane for Two Controls under a Pointwise State Constraint

Axioms
This paper concerns control BVPs, driven by ODEs x′t=ut, using controls u0· &u1· in L1a,b,R2. We ask these two controls to satisfy a very simple restriction: at points where their first coordinates coincide, also their second coordinates must coincide ...
Clara Carlota, Mário Lopes, António Ornelas   +2 more
doaj   +1 more source

Numerical Solutions of ODEs using Volterra Series [PDF]

, 2006
We propose a numerical approach for solving systems of nonautonomous ordinary di®erential equations under suitable assumptions. This approach is based on expansion of the solutions by Volterra series and allows to estimate the accuracy of the ...
Kirov, Nikolay, Krastanov, Michail
core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source