Results 81 to 90 of about 1,592 (185)

Implicit quiescent soliton perturbation in optical metamaterials with complex Ginzburg-Landau equation having nonlinear chromatic dispersion and Kudryashov's forms of self-phase modulation structures by lie symmetry. [PDF]

MethodsX
Adem AR, Arnous AH, Triki H, González-Gaxiola O, Calucag LS, Biswas A.   +5 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Postmortem brain MRI reveals differential associations of subcortical and limbic volumes with cortical thinning and neurodegenerative pathologies. [PDF]

Alzheimers Dement
Khandelwal P, Duong MT, Levorse LM, Trotman W, Bahena A, Lim SA, Denning AE, Chung E, Olm CA, Radhakrishnan H, Ittyerah R, Prabhakaran K, Mizsei G, Schuck T, Emrani S, Vizcarra JA, Robinson J, Ohm DT, Phillips JS, Cohen J, Wisse LEM, Detre JA, Nasrallah IM, Brown CA, Das SR, Lee EB, Tisdall MD, Irwin DJ, McMillan CT, Wolk DA, Yushkevich PA.   +30 more
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Phase field modelling of fracturing in frozen foods. [PDF]

Curr Res Food Sci
van der Sman R.
europepmc   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Microglia activation by derepression of endogenous retroviruses drives inflammation and cellular senescence. [PDF]

Nat Neurosci
Yan X, Georgopoulou C, Lee HM, Ahrari A, Russ J, Chandrasekar V, Ducksch T, Crispatzu G, Talevi V, Qiao L, Agrawal S, Crux S, Daman AW, Wischhof L, Stork M, Zweyer M, Zanfi ED, Chevallot-Beroux M, Li Y, De-Domenico E, Hüsson D, Bonaguro L, Li Y, Schulte-Schrepping J, Liang Q, Kessler K, Ehninger D, Rafii S, Luo J, Hermann A, Halle A, Liu Y, Mass E, Capasso M, Kato H, Schultze JL, Nicotera P, Bano D, Josefowicz SZ, Fuhrmann M, Ulas T, Beyer M, Lin J, Breteler MMB, Aziz NA, Salomoni P.   +45 more
europepmc   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Huntingtin inclusion bodies have distinct immunophenotypes and ubiquitination profiles in the Huntington's disease human cerebral cortex. [PDF]

Sci Rep
Swanson MEV, Tan AYS, Tippett LJ, Turner CP, Curtis MA, Scotter EL, Lashuel HA, Dragunow M, Faull RLM, Murray HC, Singh-Bains MK.   +10 more
europepmc   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source