Results 51 to 60 of about 1,000,822 (296)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Ostium, 2014 The problem of the translation of the expressions „ordinary language“ and „ordinary language philosophy“ is not only a question of language (how to translate it?), but also a question of philosophy (why was it called that way?). Therefore any translation
Michal Ivan
doaj
Quantification in Ordinary Language and Proof Theory
Philosophia Scientiæ, 2016 This paper gives an overview of the common approach to quantification and generalised quantification in formal linguistics and philosophy of language. We point out how this usual general framework represents a departure from empirical linguistic data. We
Michele Abrusci +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
“Putting the linguistic method in its place”: Mackie’s distinction between conceptual and factual analysis [PDF]
, 2019 Early in his career and in critical engagement with ordinary language philosophy, John Mackie developed the roots of a methodology that would be fundamental to his thinking: Mackie argues that we need to clearly separate the conceptual analysis which ...
Lossau, Tammo
core
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
Gabriel Josipovici et la fabrique de l’ordinaire
Revue LISA, 2014 This paper focuses on the idea of the ordinary in the works of Gabriel Josipovici. It argues that the ordinary in Josipovici’s works is not only a theme, but is part and parcel of the writer’s novelistic strategies, characterising both language and ...
Marcin Stawiarski
doaj +1 more source
Gender Differences in the Language of Mathematics in Secondary Schools
International Journal of Trends in Mathematics Education Research, 2020 This study investigated gender difference in students’ understanding of the language of mathematics at ordinary secondary school level in Tanzania. The participants were 489 students from 8 ordinary secondary schools.
Makungu Bulayi
doaj +1 more source
A Nonmonotonic Sequent Calculus for Inferentialist Expressivists [PDF]
, 2016 I am presenting a sequent calculus that extends a nonmonotonic consequence relation over an atomic language to a logically complex language. The system is in line with two guiding philosophical ideas: (i) logical inferentialism and (ii) logical ...
Hlobil, Ulf
core
Is the Viable System Model of organization inimical to the concept of human freedom? [PDF]
, 2006 This paper examines the sensitivity of Stafford Beer’s Viable System Model of organization to the concept of human freedom. The paper notes the many critics who have suggested that the Viable System Model is inimical to human freedom and their especial ...
Thomas, Rod
core +1 more source