Results 31 to 40 of about 59,021 (262)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Taikomoji kalbotyra, 2013 The paper deals with the representative systems of the Lithuanian language from the perspective of ordinary members of language community. The empirical data includes the names and nominations of the language variants given by ordinary members of ...
Daiva Aliūkaitė
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
A Função Adverbial de "Inteligência": Definições e Usos em Psicologia
Psicologia: Teoria e PesquisaNão há consenso em psicologia sobre a natureza, definição e nível de análise nas investigações relacionadas ao conceito de inteligência. A análise do uso deste conceito na linguagem cotidiana indicou que o mesmo exerce função adverbial, a qual ...
Jorge M. Oliveira-Castro +1 more
doaj +1 more source
Religious Language and the Problem of Truth in the Context of Ordinary Language Philosophy
Gaziantep Üniversitesi Sosyal Bilimler Dergisi, 2021 Bu çalışmanın temel amacı, doğrulama ilkesinin din dili üzerindeki etkisini ve doğrulama sorununa yönelik üretilen çözümleri incelemektir. Bu konuyu önemli kılan, özellikle mantıksal pozitivizmde, dini önermelerin doğrulanamaması sebebiyle hiçbir anlam ...
Okan Bağcı
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Theodore Jouffrey: Precursor of Ordinary Language Philosophy
Journal of French and Francophone Philosophy, 1991 - none -
James W. Manns
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Contemporary Ordinary Language Philosophy [PDF]
Philosophy Compass, 2014 Abstract There is a widespread assumption that ordinary language philosophy was killed off sometime in the 1960s or 70s by a combination of Gricean pragmatics and the rapid development of systematic semantic theory. Contrary to that widespread assumption, however, contemporary versions of ordinary language philosophy are alive and ...
openaire +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source