Results 61 to 70 of about 995,247 (301)
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
The concept jylme ‘language’ in the language and ordinary world views of Mari
Финно-угорский мир, 2018 The article describes the concept jylme ‘language’ in the Mari language. It considers the ways of representation of the concept in phraseology and in folklore texts, considering that the concept arises as a result of the interaction of national tradition
Liubov A. Abukaeva
doaj +1 more source
Metalinguistic Proposals [PDF]
, 2019 This paper sets out the felicity conditions for metalinguistic proposals, a type of directive illocutionary act. It discusses the relevance of metalinguistic proposals and other metalinguistic directives for understanding both small- and large-scale ...
Hansen, Nat
core
Reasoning About Pragmatics with Neural Listeners and Speakers
, 2016 We present a model for pragmatically describing scenes, in which contrastive behavior results from a combination of inference-driven pragmatics and learned semantics.
Andreas, Jacob, Klein, Dan
core +1 more source
FEBS Open Bio, EarlyView.Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp +13 more
wiley +1 more source
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
An HPSG approach to Welsh unbounded dependencies [PDF]
, 2010 Welsh is a language in which unbounded dependency constructions involve both gaps and resumptive pronouns (RPs). Gaps and RPs appear in disjoint sets of environments. Otherwise, however, they are quite similar.
Borsley, RD
core
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
Architectural design rewriting as an architecture description language [PDF]
, 2008 Architectural Design Rewriting (ADR) is a declarative rule-based approach for the design of dynamic software architectures. The key features that make ADR a suitable and expressive framework are the algebraic presentation of graph-based structures and ...
Bruni, Roberto +3 more
core