Results 41 to 50 of about 7,731 (299)

Asymptotic Properties of the Ordinary Least Squares Estimator in Simultaneous Equations Models [PDF]

, 2017
This paper considers the asymptotic behaviour of the ordinary least squares estimator of the coefficients of an equation from a simultaneous system. In particular, it focuses on the inconsistency of the estimator, in terms of large-sample asymptotic ...
Srivastava, V. K., Giles, D. E. A.
core   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Comparison between Linear Regression and Robust Regression Models by Using Error Criteria and Information Criteria Applied to Human Sample

Zanco Journal of Humanity Sciences
Hypertension is a common and serious disease, and for this reason, a sample of patients was chosen from Azadi Teaching Hospital in Duhok. In this study a comparison was made between Ordinary Least Squares (OLS) with two robust methods Least Trimmed ...
Ismat Mousa Ibrahim
doaj   +1 more source

Combining modified ridge-type and principal component regression estimators

Scientific African, 2020
The performance of ordinary least squares estimator (OLSE) when there is multicollinearity (MC) in a linear regression model becomes inefficient. The principal components regression and the modified ridge-type estimator have been proposed at a different ...
Adewale F. Lukman, Kayode Ayinde, Olajumoke Oludoun, Clement A. Onate   +3 more
doaj   +1 more source

A Modified Two Parameter Estimator with Different Forms of Biasing Parameters in the Linear Regression Model

African Scientific Reports, 2022
Despite its common usage in estimating the linear regression model parameters, the ordinary least squares estimator often suffers a breakdown when two or more predictor variables are strongly correlated.
Abiola T. Owolabi, Kayode Ayinde, Olusegun O. Alabi   +2 more
doaj   +1 more source

Improving weighted least squares inference [PDF]

, 2019
These days, it is common practice to base inference about the coefficients in a hetoskedastic linear model on the ordinary least squares estimator in conjunction with using heteroskedasticity consistent standard errors.
DiCiccio, Cyrus J, Wolf, Michael; https://orcid.org/, Michael Wolf, Cyrus J. DiCiccio, Romano, Joseph P, Joseph P. Romano   +5 more
core   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source