Results 51 to 60 of about 7,731 (299)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

New estimators in a partial linear model depending on an unbiased ridge regression estimator [PDF]

EPJ Web of Conferences
This paper introduces two new estimators based on the philosophy of unbiased ridge regression estimation, where the parameters are part of a partial linear model suffering from multicollinearity.
Al-Khazraji Yousif A., AIheety Mustafa I.   +1 more
doaj   +1 more source

Determinants of foreign direct investment in BRICS- does renewable and non-renewable energy matter?

Energy Strategy Reviews, 2021
The prime objective of the current research is to investigate factors affecting foreign direct investment (FDI) inflows into BRICS countries with a special focus on energy impact on FDI inflows from 1990 to 2018.
Muhammad Azam, Muhammad Haseeb
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Generalized Kibria-Lukman Estimator: Method, Simulation, and Application

Frontiers in Applied Mathematics and Statistics, 2022
In the linear regression model, the multicollinearity effects on the ordinary least squares (OLS) estimator performance make it inefficient. To solve this, several estimators are given. The Kibria-Lukman (KL) estimator is a recent estimator that has been
Issam Dawoud, Mohamed R. Abonazel, Fuad A. Awwad   +2 more
doaj   +1 more source

Improving weighted least squares inference [PDF]

, 2016
These days, it is common practice to base inference about the coefficients in a hetoskedastic linear model on the ordinary least squares estimator in conjunction with using heteroskedasticity consistent standard errors.
Romano, Joseph P., DiCiccio, Cyrus J, Wolf, Michael; https://orcid.org/, Wolf, Michael, DiCiccio, Cyrus J., Michael Wolf, Cyrus J. DiCiccio, Romano, Joseph P, Joseph P. Romano   +8 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Maximun entropy Leuven estimators and multicollinearity

Statistica, 2007
A novel class of estimators, called maximum entropy Leuven (MEL) estimators, is presented and its performance is illustrated by Monte Carlo experiments. These estimators are inspired by the theory of light.
Quirino Paris
doaj   +1 more source

The Role of Financial Reporting Quality and Disclosure Quality in Increasing Commercial Credit [PDF]

بررسی‌های حسابداری و حسابرسی, 2018
One way to increase business credit is to reduce the information asymmetry between buyer and seller. By increasing the financial reporting quality and disclosure quality, buyers can provide more information to their vendors on their financial position ...
Abbas Aflatooni, Marziye Nemati
doaj   +1 more source