Results 11 to 20 of about 104,420 (304)
Developmental regulation of canonical and small ORF translation from mRNAs
Genome Biology, 2020 Background Ribosomal profiling has revealed the translation of thousands of sequences outside annotated protein-coding genes, including small open reading frames of less than 100 codons, and the translational regulation of many genes.
Pedro Patraquim +4 more
doaj +1 more source
Cellular mRNAs access second ORFs using a novel amino acid sequence-dependent coupled translation termination-reinitiation mechanism [PDF]
, 2014 Polycistronic transcripts are considered rare in the human genome. Initiation of translation of internal ORFs of eukaryotic genes has been shown to use either leaky scanning or highly structured IRES regions to access initiation codons.
Dyer, Nigel P. +4 more
core +1 more source
AP - Open reading frames (ORFs) prediction
, 2022 Open reading frames (ORFs ...
Jessica Di Martino (11662666) +5 more
core +1 more source
Using purine skews to predict genes in AT-rich poxviruses
BMC Genomics, 2005 Background Clusters or runs of purines on the mRNA synonymous strand have been found in many different organisms including orthopoxviruses. The purine bias that is exhibited by these clusters can be observed using a purine skew and in the case of ...
Upton Chris, Da Silva Melissa
doaj +1 more source
The Hidden Enemy Within: Non-canonical Peptides in Virus-Induced Autoimmunity
Frontiers in Microbiology, 2022 Viruses play a key role in explaining the pathogenesis of various autoimmune disorders, whose underlying principle is defined by the activation of autoreactive T-cells.
Manivel Lodha +3 more
doaj +1 more source
Top 5 ORFs identified by SEQUEST.
, 2022 Top 5 ORFs identified by SEQUEST.
Ira Schildkraut (29742) +7 more
core +1 more source
Translation and natural selection of micropeptides from long non-canonical RNAs
Nature Communications, 2022 Translation of 100 to 300 micropeptides from small ORFs within lncRNA was detected by Ribosomal Profiling in Drosophila embryos. These translated small ORFs showed natural selection conserving micropeptide sequence and function.
Pedro Patraquim +4 more
doaj +1 more source
Genomic Signals of Reoriented ORFs
EURASIP Journal on Advances in Signal Processing, 2004 Complex representation of nucleotides is used to convert DNA sequences into complex digital genomic signals. The analysis of the cumulated phase and unwrapped phase of DNA genomic signals reveals large-scale features of eukaryote and prokaryote ...
Paul Dan Cristea
doaj +1 more source
OpenVar: functional annotation of variants in non-canonical open reading frames
Cell & Bioscience, 2022 Background Recent technological advances have revealed thousands of functional open reading frames (ORF) that have eluded reference genome annotations. These overlooked ORFs are found throughout the genome, in any reading frame of transcripts, mature or ...
Marie A. Brunet +2 more
doaj +1 more source
Computational analysis and mapping of novel open reading frames in influenza A viruses.
PLoS ONE, 2014 The influenza A virus contains 8 segmented genomic RNAs and was considered to encode 10 viral proteins until investigators identified the 11th viral protein, PB1-F2, which uses an alternative reading frame of the PB1 gene. The recently identified PB1-N40,
Yu-Nong Gong +4 more
doaj +1 more source