eIF1 modulates the recognition of suboptimal translation initiation sites and steers gene expression via uORFs [PDF]
, 2017 Alternative translation initiation mechanisms such as leaky scanning and reinitiation potentiate the polycistronic nature of human transcripts. By allowing for reprogrammed translation, these mechanisms can mediate biological responses to stimuli.
Fijalkowska, Daria +5 more
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Genomic Signals of Reoriented ORFs
EURASIP Journal on Advances in Signal Processing, 2004 Complex representation of nucleotides is used to convert DNA sequences into complex digital genomic signals. The analysis of the cumulated phase and unwrapped phase of DNA genomic signals reveals large-scale features of eukaryote and prokaryote ...
Paul Dan Cristea
doaj +1 more source
OpenVar: functional annotation of variants in non-canonical open reading frames
Cell & Bioscience, 2022 Background Recent technological advances have revealed thousands of functional open reading frames (ORF) that have eluded reference genome annotations. These overlooked ORFs are found throughout the genome, in any reading frame of transcripts, mature or ...
Marie A. Brunet +2 more
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Extensive Structural Variations Between Mitochondrial Genomes of CMS and Normal Peppers (Capsicum Annuum L.) Revealed by Complete Nucleotide Sequencing [PDF]
, 2014 Cytoplasmic male sterility (CMS) is an inability to produce functional pollen that is caused by mutation of the mitochondrial genome. Comparative analyses of mitochondrial genomes of lines with and without CMS in several species have revealed structural ...
Choi, Yoomi +4 more
core +2 more sources
Cellular mRNAs access second ORFs using a novel amino acid sequence-dependent coupled translation termination-reinitiation mechanism [PDF]
, 2014 Polycistronic transcripts are considered rare in the human genome. Initiation of translation of internal ORFs of eukaryotic genes has been shown to use either leaky scanning or highly structured IRES regions to access initiation codons.
Croft, Wayne D. +4 more
core +1 more source
Computational analysis and mapping of novel open reading frames in influenza A viruses.
PLoS ONE, 2014 The influenza A virus contains 8 segmented genomic RNAs and was considered to encode 10 viral proteins until investigators identified the 11th viral protein, PB1-F2, which uses an alternative reading frame of the PB1 gene. The recently identified PB1-N40,
Yu-Nong Gong +4 more
doaj +1 more source
Proteomic analysis of Glossina pallidipes salivary gland hypertrophy virus virions for immune intervention in tsetse fly colonies [PDF]
, 2010 Many species of tsetse flies (Diptera: Glossinidae) can be infected by a virus that causes salivary gland hypertrophy (SGH). The viruses isolated from Glossina pallidipes (GpSGHV) and Musca somestica (MdSGHV) have recently been sequenced.
Abd-Alla, A.M.M. +7 more
core +2 more sources
BMC Genomics, 2011 Background Recent advances in the field of metabolic engineering have been expedited by the availability of genome sequences and metabolic modelling approaches. The complete sequencing of the C.
Fan Changyu +9 more
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Using networks to analyze and visualize the distribution of overlapping genes in virus genomes.
PLoS Pathogens, 2022 Gene overlap occurs when two or more genes are encoded by the same nucleotides. This phenomenon is found in all taxonomic domains, but is particularly common in viruses, where it may increase the information content of compact genomes or influence the ...
Laura Muñoz-Baena, Art F Y Poon
doaj +1 more source
Genome sequence of a novel alloherpesvirus isolated from glass catfish (Kryptopterus bicirrhis) [PDF]
, 2018 The 149,343-bp genome of silurid herpesvirus 1, which was isolated in Thailand from glass catfish, was sequenced. The genome was most closely related to that of ictalurid herpesvirus 2, which infects black bullhead catfish. To our knowledge, this was the
Davison, Andrew J. +5 more
core +1 more source