Results 61 to 70 of about 150,284 (337)

An efficient adaptive frequency sampling scheme for large-scale transient boundary element analysis

, 2015
The frequency-domain approach (FDA) to transient analysis of the boundary element method, although is appealing for engineering applications, is computationally expensive.
Rong, Junjie, Xiao, Jinyou, Ye, Wenjing, Zhang, Chuanzeng   +3 more
core   +2 more sources

Chapparvoviruses occur in at least three vertebrate classes and have a broad biogeographic distribution [PDF]

, 2017
Chapparvoviruses are a highly divergent group of parvoviruses (family Parvoviridae) that have recently been identified via metagenomic sampling of animal faeces.
Araujo, Jansen de, Durigon, Edison Luiz, Fumagalli, Marcilio Jorge, Gifford, Robert James, Modha, Sejal, Moraes Figueiredo, Luiz Tadeu, Murcia, Pablo Ramiro, Queiroz, Luzia Helena [UNESP], Romeiro, Marilia Farignoli, Souza, William Marciel de   +9 more
core   +2 more sources

Silencing Myostatin Using In Vivo Self‐Assembled siRNA Protects Against Cancer‐ and Dexamethasone‐Induced Muscle Atrophy

Advanced Healthcare Materials, EarlyView.
This study reports an in vivo self‐assembled siRNA strategy that enables the liver to generate small extracellular vesicles (sEVs) tagged with a muscle‐targeting peptide (MSP) and naturally loaded with myostatin (MSTN)‐siRNA. These MSP‐tagged sEVs are systemically delivered to skeletal muscle, efficiently silence MSTN, promote muscle hypertrophy, and ...
Xin Yin, Azhar Anwar, Jiehao Chen, Qinghao Sun, Likun Zhou, Jie Tang, Jingwei Guo, Linbo Yan, Yongci Chen, Feng Yin, Chen‐Yu Zhang, Zigang Li, Jizheng Ma, Liyuan Sheng, Xi Chen   +14 more
wiley   +1 more source

Global transcriptional response of Escherichia coli O157:H7 to growth transitions in glucose minimal medium

BMC Microbiology, 2007
Background: Global patterns of gene expression of Escherichia coli K-12 during growth transitions have been deeply investigated, however, comparable studies of E.
Ouellette Lindsey M, Riordan James T, Qi Weihong, Wick Lukas M, Bergholz Teresa M, Whittam Thomas S   +5 more
doaj   +1 more source

The Alliance for Cellular Signaling Plasmid Collection: A Flexible Resource for Protein Localization Studies and Signaling Pathway Analysis [PDF]

, 2007
Cellular responses to inputs that vary both temporally and spatially are determined by complex relationships between the components of cell signaling networks.
Bryan, Heather, Chandy, Grischa, Chang, Mi Sook, Coutre, Sam, Dhandapani, Kavitha, Driver, Adrienne, Fraser, Iain D. C., Fung, Eileen, Gehrig, Elizabeth, Kivork, Christine, Lee, Genie, Liu, Jamie, Lyon, Stephen, Maer, Andreia, Meyer, Tobias, Mi, Qingli, Ning, Yuhong, O'Rourke, Nancy, Park, Wei Sun, Randhawa, Baljinder, Santat, Leah, Saunders, Brian, Simon, Melvin I., Subramaniam, Shankar, Verghese, Mary, Wall, Estelle, Whalen, James, Zavzavadjian, Joelle R., Zhu, Xiaocui   +28 more
core   +1 more source

On the extent and role of the small proteome in the parasitic eukaryote Trypanosoma brucei [PDF]

, 2014
Background: Although technical advances in genomics and proteomics research have yielded a better understanding of the coding capacity of a genome, one major challenge remaining is the identification of all expressed proteins, especially those less than ...
Butter, F., Ericson, M., Janes, M., Mann, M., Tschudi, C., Ullu, E.   +5 more
core   +2 more sources

Ferritin‐Doped Nanoparticles Triggered Tumor‐Specific Darkening for Enhanced Photothermal Tumor Ablation and Immune Activation

Advanced Healthcare Materials, EarlyView.
Ferritin‐doped hybrid nanoparticles triggered accurate tumor‐specific hemorrhage for enhanced in situ photothermal therapy and evoked anti‐tumor immunity. Notably, HFn/GA‐Fe specifically induced tumor hemorrhage 12 h after intravenous injection, resulting in visible color darkening. Through photoacoustic imaging, tumor vessels could be clearly observed
Haidong Zha, Xiao Liang, Long Xi, Jiamao Chen, Wenzhao Zhong, Zhen Yuan, Meng Xu, Ying Zheng   +7 more
wiley   +1 more source

CYP2C9 and CYP2C19: Deep Mutational Scanning and Functional Characterization of Genomic Missense Variants

Clinical and Translational Science, 2020
Single nucleotide variants in the open reading frames (ORFs) of pharmacogenes are important causes of interindividual variability in drug response. The functional characterization of variants of unknown significance within ORFs remains a major challenge ...
Lingxin Zhang, Vivekananda Sarangi, Irene Moon, Jia Yu, Duan Liu, Sandhya Devarajan, Joel M. Reid, Krishna R. Kalari, Liewei Wang, Richard Weinshilboum   +9 more
doaj   +1 more source

Detection of conjugation related type four secretion machinery in Aeromonas culicicola. [PDF]

PLoS ONE, 2006
BACKGROUND: Aeromonas sp. can now be considered relatively common enteropathogens due to the increase of diseases in humans. Aeromonas culicicola is a gram negative rod-shaped bacterium isolated for the first time from the mosquito mid-gut, but ...
Ashraf Yusuf Rangrez, Kannayakanahalli Maheshwarappa Dayananda, Santosh Atanur, Rajendra Joshi, Milind S Patole, Yogesh S Shouche   +5 more
doaj   +1 more source

First‐Principles Structure–Activity Relationship Insights Into Phenolic Scaffolds: QSAR Modeling and Drug‐Likeness Screening

Advanced Theory and Simulations, EarlyView.
Integrated machine learning framework for phenolic derivatives: classification (toxicity) and regression (logP) models identify top drug‐like compounds. Random Forest outperformed for toxicity, while Linear Regression best predicted logP. A weighted scoring approach prioritized five safe, lipophilicity‐optimized candidates, supporting rational ...
Houria Nacer, Sridhar Priyankha, Gopal Hema, Anouar Zerouali, Hamza Haddag, Muneerah Mogren Al Mogren, Muthuramalingam Prakash, Majdi Hochlaf   +7 more
wiley   +1 more source