Results 301 to 310 of about 69,325 (340)
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Lab on a Chip
The retina is a complex and highly metabolic tissue in the back of the eye essential for human vision. Retinal diseases can lead to loss of vision in early and late stages of life, significantly affecting patients' quality of life.
Tarek Gensheimer +5 more
semanticscholar +1 more source
The retina is a complex and highly metabolic tissue in the back of the eye essential for human vision. Retinal diseases can lead to loss of vision in early and late stages of life, significantly affecting patients' quality of life.
Tarek Gensheimer +5 more
semanticscholar +1 more source
Organ-on-Chip platforms to study tumor evolution and chemosensitivity.
Biochimica et biophysica acta. Reviews on cancer, 2022Despite tremendous advancements in oncology research and therapeutics, cancer remains a primary cause of death worldwide. One of the significant factors in this critical challenge is a precise diagnosis and limited knowledge on how the tumor ...
Venzil Lavie Dsouza +3 more
semanticscholar +1 more source
Progress in Molecular Biology and Translational Science, 2022
The high failure rate in drug development is often attributed to the lack of accurate pre-clinical models that may lead to false discoveries and inconclusive data when the compounds are eventually tested in clinical phase.
J. Lacombe +2 more
semanticscholar +1 more source
The high failure rate in drug development is often attributed to the lack of accurate pre-clinical models that may lead to false discoveries and inconclusive data when the compounds are eventually tested in clinical phase.
J. Lacombe +2 more
semanticscholar +1 more source
Lab on a Chip, 2021
Membranes play a crucial role in many microfluidic systems, enabling versatile applications in highly diverse research fields. However, the tight and robust integration of membranes into microfluidic systems requires complex fabrication processes.
Stefan Schneider +3 more
semanticscholar +1 more source
Membranes play a crucial role in many microfluidic systems, enabling versatile applications in highly diverse research fields. However, the tight and robust integration of membranes into microfluidic systems requires complex fabrication processes.
Stefan Schneider +3 more
semanticscholar +1 more source
Microfabrication of human organs-on-chips
Nature Protocols, 2013'Organs-on-chips' are microengineered biomimetic systems containing microfluidic channels lined by living human cells, which replicate key functional units of living organs to reconstitute integrated human organ-level pathophysiology in vitro. These microdevices can be used to test efficacy and toxicity of drugs and chemicals, and to create in vitro ...
Dongeun, Huh +7 more
openaire +2 more sources
Lab on a Chip
The effects of endocrine-disrupting compounds (EDCs) on the placenta, a critical gestational organ for xenobiotic protection, are well reported; however, models to determine the role of EDCs in placental disruption are limited. An advanced 2nd- trimester
Manuel S Vidal +10 more
semanticscholar +1 more source
The effects of endocrine-disrupting compounds (EDCs) on the placenta, a critical gestational organ for xenobiotic protection, are well reported; however, models to determine the role of EDCs in placental disruption are limited. An advanced 2nd- trimester
Manuel S Vidal +10 more
semanticscholar +1 more source
Lab on a Chip
Biological barriers such as the blood-brain barrier, skin, and intestinal mucosal barrier play key roles in homeostasis, disease physiology, and drug delivery - as such, it is important to create representative in vitro models to improve understanding of
Alisa Ugodnikov +2 more
semanticscholar +1 more source
Biological barriers such as the blood-brain barrier, skin, and intestinal mucosal barrier play key roles in homeostasis, disease physiology, and drug delivery - as such, it is important to create representative in vitro models to improve understanding of
Alisa Ugodnikov +2 more
semanticscholar +1 more source
2016
The process of new drug development is both time and cost intensive. Therefore, all test systems, in particular during the pre-clinical phase, have to provide reliable results to minimize the risk of failure at a later stage of drug development. However, current pre-clinical studies are mainly performed using experimental animals and in vitro cell ...
N. Beißner, T. Lorenz, S. Reichl
openaire +1 more source
The process of new drug development is both time and cost intensive. Therefore, all test systems, in particular during the pre-clinical phase, have to provide reliable results to minimize the risk of failure at a later stage of drug development. However, current pre-clinical studies are mainly performed using experimental animals and in vitro cell ...
N. Beißner, T. Lorenz, S. Reichl
openaire +1 more source
Cell Host and Microbe, 2021
The important and diverse roles of the gut microbiota in human health and disease are increasingly recognized. The difficulty of inferring causation from metagenomic microbiome sequencing studies and from mouse-human interspecies differences has prompted the development of sophisticated in vitro models of human gut-microbe interactions. Here, we review
Puschhof, Jens +2 more
openaire +1 more source
The important and diverse roles of the gut microbiota in human health and disease are increasingly recognized. The difficulty of inferring causation from metagenomic microbiome sequencing studies and from mouse-human interspecies differences has prompted the development of sophisticated in vitro models of human gut-microbe interactions. Here, we review
Puschhof, Jens +2 more
openaire +1 more source
Biomaterials, 2019
Epithelial cells experience constant mechanical forces, including fluid shear stress (FSS) on their apical surface. These forces alter both structure and function.
Ludivine C. Delon +6 more
semanticscholar +1 more source
Epithelial cells experience constant mechanical forces, including fluid shear stress (FSS) on their apical surface. These forces alter both structure and function.
Ludivine C. Delon +6 more
semanticscholar +1 more source