Mutations in the PERIANTHIA gene of Arabidopsis specifically alter floral organ number and initiation pattern [PDF]
, 1996 An open question in developmental biology is how groups of dividing cells can generate specific numbers of segments or organs. We describe the phenotypic effects of mutations in PERIANTHIA, a gene specifically required for floral organ patterning in ...
Meyerowitz, Elliot M., Running, Mark P.
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Organ Transplantation from the Deceased [PDF]
, 1968 Loening in a Parks class filled with students.
Guttentag, Otto E.
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Sorry Buddy, But Your Name Isn\u27t on the List: Fear and the Ethics of Organ Donation in Film [PDF]
, 2012 The fear of death and illness is a powerful motivator. When taking into account the ethical reasoning that drives organ transplantation and procurement practices, it is persuasive enough to sway minds and corrupt pure reason.
Callis, Ted
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Teaching in Context: Integrating Mathematical Thinking and Personal Development Planning into the Curriculum for Part-Time, Distance-Learning Engineering Students [PDF]
, 2018 This paper describes changes to the way mathematics is taught to engineering students at The Open University, moving away from service teaching via generic mathematics modules to incorporating mathematics teaching into the core engineering curriculum ...
Goodyear, Alec +2 more
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
EVALUASI BERAT RELATIF ORGAN GIZZARD, USUS HALUS DAN HATI PADA BROILER [PDF]
Penelitian ini bertujuan untuk mengetahui berat relatif organ gizzard, usus halus dan hati pada broiler di Rumah Pemotongan Ayam Era Cipta 2, Lamongan. Penelitian ini menggunakan broiler dengan strain manggis dan berjumlah 30 ekor dengan bobot antara 1 ...
Fahami, Moh Farid
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Using Blockchain Technology for The Organ Procurement and Transplant Network [PDF]
, 2019 The organ donation system in the United States is centralized and difficult to audit by the general public. This centralized approach may lead to data integrity issues in the future.
Jain, Utsav
core +1 more source