Results 71 to 80 of about 3,465,396 (303)

THE “NEW BODY SNATCHERS”: ANALYZING THE EFFECT OF PRESUMED CONSENT ORGAN DONATION LAWS ON PRIVACY, AUTONOMY, AND LIBERTY [PDF]

, 2011
This Note examines, in three parts, presumed consent laws as they pertain to organ donation. Part I discusses presumed consent and explains the salient features of presumed consent laws.
Liddy, Maryellen
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

The Heart Is Not an Animated Body: Machines of Nature, Functional Organs and Monadic Domination in Leibniz

Journal of Modern Philosophy
For the mature Leibniz, the organic bodies of living beings or substances are “machines of nature” containing both infinitely many (a) functional bodily organs and (b) further substances. These latter substances are said to be dominated by or subordinate
Christopher P Noble
doaj   +2 more sources

My own Passion compositions. Inspirations, texts, composing technique, musical language

Edukacja Muzyczna, 2019
This article is devoted to my own Lenten choral and organ music. At first, I introduce my mo- tives for undertaking creative activity, which include, among others, the atmosphere of my family house (my father, Wojciech Łukaszewski, was a composer).
Marcin Tadeusz ŁUKASZEWSKI
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Economic Impact and Disease Insights: Understanding Organ Condemnation in Cattle Slaughtered at Bahir Dar Abattoir

Veterinary Medicine and Science
Background Abattoir surveillance is the font of valuable information on the incidence and epidemiology of animal disease, having both public and animal health importance.
Habtamu Endale, Mesfin Mathewos
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Future aspects of renal transplantation [PDF]

, 1988
New and exciting advances in renal transplantation are continuously being made, and the horizons for organ transplantation are bright and open. This article reviews only a few of the newer advances that will allow renal transplantation to become even ...
A Kawaguchi, A Palmer, A. G. Tzakis, B Kahan, E Reed, FO Belzer, H Sollinger, H Tighe, I Koyama, J Chehimi, JM McCord, L Makowka, L Makowka, L Makowka, L. Makowka, NA Halasz, R. Shapiro, RJ Taylor, RY Calne, S Todo, S Todo, T Rosenthal, T. E. Starzl, TE Starzl, TE Starzl, TE Starzl, W. B. Lopatin   +26 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Dietary supplementation with Punica and Physalis attenuates the deleterious effects of fenitrothion in rats

Zagazig Journal of Pharmaceutical Sciences, 2014
Exposure to pesticides may result in several health hazards including liver impairment which might be followed by impairment of brain functions or renal functions.
Rasha Abdel-Ghany , Ebaa Mohammed , Shimaa Anis , Ahmed Bihery , Waleed Barakat   +4 more
doaj   +1 more source