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Development of an Ex Vivo Organ Culture Technique to Evaluate Probiotic Utilization in IBD [PDF]

open access: greenJournal of Clinical Gastroenterology, 2016
The consistent technical and conceptual progress in the study of the microbiota has led novel impulse to the research for therapeutical application of probiotic bacteria in human pathologies, such as inflammatory bowel disease (IBD). Considering the heterogenous results of probiotics in clinical studies, the model of translational medicine may lead to ...
Pagnini, C   +3 more
core   +7 more sources

Experimental liver models: From cell culture techniques to microfluidic organs‐on‐chip [PDF]

open access: bronzeLiver International, 2021
AbstractThe liver is one of the most studied organs of the human body owing to its central role in xenobiotic and drug metabolism. In recent decades, extensive research has aimed at developing in vitro liver models able to mimic liver functions to study pathophysiological clues in high‐throughput and reproducible environments.
Polidoro M. A.   +4 more
openaire   +3 more sources

Biological Effects of Clinically Relevant CoCr Nanoparticles in the Dura Mater: An Organ Culture Study [PDF]

open access: yesNanomaterials, 2014
Medical interventions for the treatment of spinal disc degeneration include total disc replacement and fusion devices. There are, however, concerns regarding the generation of wear particles by these devices, the majority of which are in the nanometre ...
Iraklis Papageorgiou   +5 more
doaj   +4 more sources

Design and Fabrication of Organ-on-Chips: Promises and Challenges

open access: yesMicromachines, 2021
The advent of the miniaturization approach has influenced the research trends in almost all disciplines. Bioengineering is one of the fields benefiting from the new possibilities of microfabrication techniques, especially in cell and tissue culture ...
Alireza Tajeddin, Nur Mustafaoglu
doaj   +2 more sources

The nerve center of organ engineering [PDF]

open access: yesNature Communications
Engineering replacement organs is the next frontier in therapeutic technologies. Yet, the integration of innervation—critical for organ development, function, and homeostasis—remains underexplored.
Suradip Das   +5 more
doaj   +2 more sources

Induction of Cell Proliferation in Rat Utricles Using Organ Culture Technique

open access: diamondEquilibrium Research, 2003
In mammals, the loss of vestibular hair cells appears to lead to limited proliferation of supporting cells in vivo.However, recent studies have indicated that active cell proliferation can be induced by brief exposure to forskolin in cultured utricles using the seat culture technique. The aim of this study was to examine whether such cell proliferation
Takayuki Nakagawa   +6 more
openaire   +3 more sources

Advances and Applications of Organ-on-a-Chip and Tissue-on-a-Chip Technology [PDF]

open access: yesBioengineering
Organ-on-a-chip (OoC) or tissue-on-a-chip (ToC) technologies represent a significant advancement in enabling modeling of human organ and tissue physiology for medical study, although further development is required for these technologies to reach ...
Megan Moore   +3 more
doaj   +2 more sources

Detection of infectious bronchitis virus in tracheal organ cultures using the immunoperoxidase technique

open access: gold, 2002
The applicability of the immunoperoxidase (IP) technique in unfixed-fresh tracheal organ cultures (TOCs) was investigated for rapid detection of infectious bronchitis virus (IBV). For this purpose, TOCs prepared from one-day-old SPF chicks were inoculated with IBV M41 strain in serial dilutions.
Şen, A.   +3 more
openaire   +6 more sources

Barrier-on-a-Chip with a Modular Architecture and Integrated Sensors for Real-Time Measurement of Biological Barrier Function

open access: yesMicromachines, 2021
Biological barriers are essential for the maintenance of organ homeostasis and their dysfunction is responsible for many prevalent diseases. Advanced in vitro models of biological barriers have been developed through the combination of 3D cell culture ...
Patrícia Zoio   +2 more
doaj   +1 more source

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