Results 21 to 30 of about 109,114 (263)

Describing organ dysfunction in the intensive care unit: a cohort study of 20,000 patients

Critical Care, 2019
Background Multiple organ dysfunction is a common cause of morbidity and mortality in intensive care units (ICUs). Original development of the Sequential Organ Failure Assessment (SOFA) score was not to predict outcome, but to describe temporal changes ...
Andrea Soo, Danny J. Zuege, Gordon H. Fick, Daniel J. Niven, Luc R. Berthiaume, Henry T. Stelfox, Christopher J. Doig   +6 more
doaj   +1 more source

Early lactate clearance is associated with biomarkers of inflammation, coagulation, apoptosis, organ dysfunction and mortality in severe sepsis and septic shock

Journal of Inflammation, 2010
Background Lactate clearance, a surrogate for the magnitude and duration of global tissue hypoxia, is used diagnostically, therapeutically and prognostically.
Suarez Arturo, Otero Ronny M, Shah Kant, Jacobsen Gordon, Yang James J, Loomba Manisha, Nguyen H Bryant, Parekh Hemal, Jaehne Anja, Rivers Emanuel P   +9 more
doaj   +1 more source

Association of High Serum Adiponectin with the Risk of Malnutrition and Worse Outcome in Head Trauma Patients; a Cohort study

Archives of Academic Emergency Medicine, 2019
Introduction: A number of studies have shown the association between serum adiponectin level and the nutritional status. This study aimed to evaluate the relation between serum adiponectin and changes in nutritional status of head trauma patients ...
Mohammed Ibrahim Mohialdeen Gubari, Mohammad Javad Hosseinzadeh-Attar, Mostafa Hosseini, Fadhil Ahmed Mohialdeen, Abdolreza Norouzy   +4 more
doaj   +1 more source

European Society of Intensive Care Medicine и Society of Critical Care Medicine: 6 key provisions for management of sepsis patients. Where do we go next?

Вестник анестезиологии и реаниматологии, 2020
The objective: to analyze the validity of recommendations of the special research committee of the European Society of Intensive Care Medicine (ESICM) and Society of Critical Care Medicine (SCCM) concerning the most important provisions for the ...
V. A. Rudnov, V. A. Bagin, M. N. Аstafieva   +2 more
doaj   +1 more source

Utility of SOFA score, management and outcomes of sepsis in Southeast Asia: a multinational multicenter prospective observational study

Journal of Intensive Care, 2018
Background Sepsis is a global threat but insufficiently studied in Southeast Asia. The objective was to evaluate management, outcomes, adherence to sepsis bundles, and mortality prediction of maximum Sequential Organ Failure Assessment (SOFA) scores in ...
Khie Chen Lie, Chuen-Yen Lau, Nguyen Van Vinh Chau, T. Eoin West, Direk Limmathurotsakul, for Southeast Asia Infectious Disease Clinical Research Network   +5 more
doaj   +1 more source

Sepsis in Patients With Large Vessel Occlusion Stroke–Clinical Characteristics and Outcome

Frontiers in Neurology, 2022
BackgroundInfections are an important complication after stroke and negatively affect clinical outcome. While pneumonia and urinary tract infections are well recognized after stroke, the incidence and consequences of sepsis remain unclear.
Sebastian Stösser, Julia Isakeit, Felix J. Bode, Christian Bode, Gabor C. Petzold   +4 more
doaj   +1 more source

Pediatric Sepsis Definition—A Systematic Review Protocol by the Pediatric Sepsis Definition Taskforce

Critical Care Explorations, 2020
Objectives:. Sepsis is responsible for a substantial proportion of global childhood morbidity and mortality. However, evidence demonstrates major inaccuracies in the use of the term “sepsis” in clinical practice, coding, and research.
Kusum Menon, MD, MSc, Luregn J. Schlapbach, MD, Samuel Akech, MBChB, MMED, Andrew Argent, MBBCh, MD, Kathleen Chiotos, MD, MSCE, Mohammod Jobayer Chisti, MBBS, MMed, PhD, Jemila Hamid, PhD, Paul Ishimine, MD, Niranjan Kissoon, MD, Rakesh Lodha, MD, Cláudio Flauzino Oliveira, MD, Mark Peters, MBChB, PhD, Pierre Tissieres, MD, PhD, R. Scott Watson, MD, MPH, Matthew O. Wiens, PharmD, PhD, James L. Wynn, MD, Lauren R. Sorce, BSN, PhD, for the Pediatric Sepsis Definition Taskforce of the Society of Critical Care Medicine, Luregn J. Schlapbach, R. Scott Watson, Andrew Argent, Lauren R. Sorce, Elizabeth R. Alpern, Fran Balamuth, Tellen D. Bennett, Paolo Biban, Joe Carcillo, Enitan Carrol, Kathleen Chiotos, Mohammod Jobayer Chisti, Idris Evans, Lu Guoping, Mark W. Hall, David Inwald, Paul Ishimine, Michael Levin, Niranjan (Tex) Kissoon, Rakesh Lodha, Kathryn Maitland, Simon Nadel, Satoshi Nakagawa, Claudio Flauzino Oliveira, Mark Peters, Adrienne G. Randolph, Suchitra Ranjit, L. Nelson Sanchez-Pinto, Halden F. Scott, Daniela Carla Souza, Paul Tissieres, Juliane Bubeck Wardenburg, Scott L. Weiss, Wilson Milton Were, Matt Wiens, James L. Wynn, Jerry J. Zimmerman   +54 more
doaj   +1 more source

PO-0478 Multi-organ Dysfunction Scoring In Neonatal Encephalopathy [PDF]

Archives of Disease in Childhood, 2014
Background Neonatal encephalopathy secondary to perinatal asphyxia in term infants commonly results in multi-organ dysfunction (MOD). However methods to accurately and objectively quantify the degree of MOD in NE are lacking. Objective To develop a scoring system which accurately reflects the degree of MOD in NE and to assess the ability of this ...
DU Sweetman, JFA Murphy, V Donoghue, R Segurado, EJ Molloy   +4 more
openaire   +1 more source

Assessing the Course of Organ Dysfunction Using Joint Longitudinal and Time-to-Event Modeling in the Vasopressin and Septic Shock Trial

Critical Care Explorations, 2020
Objectives:. Non-mortality septic shock outcomes (e.g., Sequential Organ Failure Assessment score) are important clinical endpoints in pivotal sepsis trials. However, comparisons of observed longitudinal non-mortality outcomes between study groups can be
Michael O. Harhay, PhD, Alessandro Gasparini, PhD, Allan J. Walkey, MD, MS, Gary E. Weissman, MD, MSHP, Michael J. Crowther, PhD, Sarah J. Ratcliffe, PhD, James A. Russell, MD, on behalf of the Vasopressin and Septic Shock Trial (VASST) Investigators, J. A. Russell, K. R. Walley, C. L. Holmes Boulton, J. T. Granton, P. C. Hebert, D. J. Cooper, S. Mehta, J. Singer, A. C. Gordon, M. M. Storms, S. Jones, J. A. Russell, M. M. Storms, K. R. Walley, G. R. Bernard, A. S. Slutsky, G. A. Wells, A. Gasparini, B. Savage, D. Ayers, R. Woods, K. Wu, M. Maralit, L. Smith, K. Foley, A. Suri, M. Steinberg, B. Howe, P. Galt, A. Higgins, M. M. Storms, M. E. LeBlanc, A. M. Sutherland, A. Sham, A. McLeod, D. R. Dorscheid, M. Hameed, L. Lazosky, S. Helderweirt, C. Honeyman, T. Terins, D. Chittock, J. Ronco, L. Smith, S. Logie, G. Wood, F. Auld, V. Stedham, M. Mantle, L. Fox, G. D. McCauley, J. D. Rolf, C. Erbacher, G. Martinka, S. Goulding, S. Silverwood, L. Leung, S. Keenan, J. Murray, M. Van Osch, B. Light, M. Dominique, P. Gray, R. Stimpson, S. Rosser, D. Bell, W. Janz, P. C. Hebert, T. McArdle, I. Watpool, J. T. Granton, M. Steinberg, A. Matte-Martyn, D. J Cook, E. McDonald, F. Clarke, A. Tkaczyk, N. Zytaruk, T. Stewart, A. Suri, C. Martinez-Motta, R. MacDonald, V. Sivanantham, R. Hodder, J. Foxall, M. Lewis, M. Ward, C. Dos Santos, J. Friedrich, D. Scales, O. Smith, I. DeCampos, A. Richards, H. Michalopoulos, U. Bakshi, W. Sibbald, T. Smith, K. Code, B. Bojilov, C. Dale, M. Keogh, M. Meade, L. Hand, C. Martin, J. Kehoe, V. Binns, M. McGuire, G. Poirier, L. Provost, J. Muscedere, C. Diemer, D. J. Cooper, V. Pellegrino, A. Hilton, S. Morrison, C. Weatherburn, K. Moulden, C. Harry, J. J. Presneill, M. S Robertson, J. F. Cade, B. D. Howe, D. K. Barge, C. A. Boyce, F. Healy, C. Wright, D. Weyandt, J. Barrett, C. Walker, P. Galt, S. Burton, G. Dobb, S. Perryman, J. Chamberlain, L. Thomas, A. Bersten, L. Daly, T. Hunt, D. Wood, B. Patel, J. Larson, M. Rady, G. LeBrun, E. Boyd, R. Rush   +152 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source