Results 31 to 40 of about 109,114 (263)

Association between oxygen debt (DEOx) variability over time and clinical outcomes in critically ill COVID-19 patients: an observational study

BMC Pulmonary Medicine
Background Oxygen debt (DEOx) quantifies oxygen deficit during shock, reflecting the transition to anaerobic metabolism due to decreased oxygen delivery (DO₂).
Eduardo Tuta-Quintero, Alirio Bastidas-Goyes, Henry Robayo-Amortegui, Michel Pérez-Garzón, Isacio Serna-Palacios, Cristian Peña-Quimbayo, Julian Espitia, Daniel Pinto, Johan Rincón, Juan Sánchez, Jesus Pérez   +10 more
doaj   +1 more source

Severity assessment of acute pancreatitis: applying Marshall scoring system

Revista do Colégio Brasileiro de Cirurgiões
Objective: To analyze the effectiveness of the Marshall scoring system to evaluate the severity of acute pancreatitis (AP). Methods : We performed a prospective, observational study in 39 patients with AP evaluated by the Marshall scoring system and ...
André Lanza Carioca, Debora Rodrigues Jozala, Lucas Oliveira de Bem, Jose Mauro da Silva Rodrigues   +3 more
doaj   +1 more source

Predisposition, Insult, Response, and Organ Dysfunction: A Well-constructed Score!

Indian Journal of Critical Care Medicine, 2023
How to cite this article: Kannan A, Jindal A. Predisposition, Insult, Response, and Organ Dysfunction: A Well-constructed Score! Indian J Crit Care Med 2023;27(2):150.
Kannan, Abinaya, Jindal, Atul
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Performance of Sequential Organ Failure Assessment, Logistic Organ Dysfunction and Multiple Organ Dysfunction score in severe sepsis within Chinese intensive care units [PDF]

Anaesthesia and Intensive Care, 2011
This study assessed the performance of Sequential Organ Failure Assessment, Logistic Organ Dysfunction Score and Multiple Organ Dysfunction Score in outcome prediction in severe sepsis. A total of 528 consecutive patients with a diagnosis of severe sepsis were enrolled from two surgical intensive care units of university hospitals in China.
H, Wang, L, Ye, L, Yu, G, Xie, B, Cheng, X, Liu, Y, Jin, S, Wu, T, Zhu, Q, Chen, X, Fang   +10 more
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

SOFA nas primeiras 24 horas como preditor de desfecho em insuficiência hepática aguda

Revista Brasileira de Terapia Intensiva
RESUMO Objetivo: Descrever uma coorte de doentes com insuficiência hepática aguda, e analisar os fatores demográficos e clínicos associados à mortalidade.
Edison Moraes Rodrigues-Filho, Rogério Fernandes, Anderson Garcez   +2 more
doaj   +1 more source

Recombinant Activated Factor VII as a Second Line Treatment for Postpartum Hemorrhage [PDF]

Korean Journal of Critical Care Medicine, 2017
Background Severe or massive postpartum hemorrhage (PPH) has remained a leading cause of maternal mortality for decades across the world and it results in critical obstetric complications.
Soon Chang Park, Seok Ran Yeom, Sang Kyoon Han, Young Mo Jo, Hyung Bin Kim   +4 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source