Results 51 to 60 of about 2,364,274 (318)

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Sirtuin 3 in renal diseases and aging: From mechanisms to potential therapies

Pharmacological Research
The longevity protein sirtuins (SIRTs) belong to a family of nicotinamide adenine dinucleotide (NAD+)-dependent deacetylases. In mammals, SIRTs comprise seven members (SIRT1–7) which are localized to different subcellular compartments.
Xuan Peng, Haiqiang Ni, Baicheng Kuang, Zhiheng Wang, Shuaiheng Hou, Shiqi Gu, Nianqiao Gong   +6 more
doaj   +1 more source

Impact of para aortic lymph node removal on survival following resection for pancreatic adenocarcinoma

BMC Surgery, 2023
Introduction For PDAC patients undergoing resection, it remains unclear whether metastases to the paraaortic lymph nodes (PALN+) have any prognostic significance and whether metastases should lead to the operation not being carried out. Our hypothesis is
Martin Sillesen, Carsten Palnæs Hansen, Stefan Kobbelgaard Burgdorf, Emilie Even Dencker, Paul Suno Krohn, Sophie Louise Gisela Kollbeck, Mogens Tornby Stender, Jan Henrik Storkholm   +7 more
doaj   +1 more source

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

FEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar, Michael A. Ripperger, Grant M. Westlake, Kevin C. Ess   +3 more
wiley   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

Longitudinal profiling of gut microbiota dynamics in kidney transplant recipients

Journal of Translational Medicine
Background The gut microbiota undergoes substantial alterations in kidney transplant recipients, which are linked to postoperative complications and renal function recovery. However, the underlying mechanisms of these associations remain unclear. Methods
Weibo Zhong, Runtao Feng, Haoxin Liang, Jianmin Hu, Song Zhou, Ding Liu, Shichao Li, Guorong Liao, Jun Liao, Siqiang Yang, Ya Zhang, Xinyun Xiao, Jun Qian, Hua Chen, Lipei Fan, Min Li, Ming Zhao, Jianrong Chen, Yongguang Liu   +18 more
doaj   +1 more source

Current Practices on Diagnosis, Prevention and Treatment of Post-Transplant Lymphoproliferative Disorder in Pediatric Patients after Solid Organ Transplantation: Results of ERN TransplantChild Healthcare Working Group Survey [PDF]

, 2021
Alastair Baker, Esteban Frauca Remacha, Juan Manuel Torres, Luz Yadira Bravo‐Gallego, Emer Fitzpatrick, Á. Alonso Melgar, Gema Muñoz Bartolo, Luis García‐Guereta, Esther Ramos Boluda, Yasmina Mozo, Dorota Broniszczak, Wioletta Jarmużek, Piotr Kaliciński, Britta Maecker‐Kolhoff, Julia Carlens, Ulrich Baumann, Charlotte Roy, Christophe Chardot, Elisa Benetti, Mara Cananzi, Elisabetta Calore, Luca Dello Strologo, M. Candusso, Maria Francelina Lopes, Manuel Brito, Cristina Gonçalves, Carmén do Carmo, Xavier Stéphenne, Lars Wennberg, Rosário Stone, Jelena Rascon, Caroline A. Lindemans, Dominik Turkiewicz, Eugenia Giraldi, Emanuele Nicastro, Lorenzo D’Antiga, O. Ackermann, Paloma Jara   +37 more
openalex   +1 more source

Regenerative medicine, organ bioengineering and transplantation

British Journal of Surgery, 2020
Organ transplantation is predicted to increase as life expectancy and the incidence of chronic diseases rises. Regenerative medicine‐inspired technologies challenge the efficacy of the current allograft transplantation model.
Lauren Edgar, T. Pu, B. Porter, J. M. Aziz, C. L. Pointe, Amish Asthana, Giuseppe Orlando   +6 more
semanticscholar   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Daratumumab followed by tocilizumab for treatment of late antibody-mediated rejection in renal transplant recipients with high or moderate levels of de novo donor-specific antibodies: a pilot study

BMC Nephrology
Background Effective treatment of late antibody-mediated rejection (late AMR) is still an unmet medical need. Clearing donor-specific antibody (DSA) and preventing its rebound is the ideal goal of treatment.
Zhiliang Guo, Rula Sa, Daqiang Zhao, Songxia Li, Hui Guo, Lan Zhu, Gang Chen   +6 more
doaj   +1 more source