Results 41 to 50 of about 440,505 (312)

An integrated machine learning model enhances delayed graft function prediction in pediatric renal transplantation from deceased donors

BMC Medicine
Background Kidney transplantation is the optimal renal replacement therapy for children with end-stage renal disease; however, delayed graft function (DGF), a common post-operative complication, may negatively impact the long-term outcomes of both the ...
Xiao-You Liu, Run-Tao Feng, Wen-Xiang Feng, Wei-Wei Jiang, Jian-An Chen, Guang-Li Zhong, Chao-Wei Chen, Zi-Jian Li, Jia-Dong Zeng, Ding Liu, Song Zhou, Jian-Min Hu, Guo-Rong Liao, Jun Liao, Ze-Feng Guo, Yu-Zhu Li, Si-Qiang Yang, Shi-Chao Li, Hua Chen, Ying Guo, Min Li, Li-Pei Fan, Hong-Yan Yan, Jian-Rong Chen, Liu-Yang Li, Yong-Guang Liu   +25 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Bone marrow mesenchymal stem cells alleviate liver fibrosis after rat liver transplantation through JAK1/STAT5 pathway

Stem Cell Research & Therapy
Objective The effectiveness of bone marrow mesenchymal stem cells (BMSCs) in post-transplantation liver fibrosis has not been studied. The aim of this study was to investigate the effect of BMSCs on liver fibrosis and their role in the Janus-activated ...
Zhuyuan Si, Shengqiao Zhao, Zhixin Zhang, Tianran Chen, Ruofan Wang, Chong Dong, Kai Wang, Chao Sun, Zhuolun Song, Zhongyang Shen, Wei Gao   +10 more
doaj   +1 more source

Preparation and characterization of small-diameter decellularized scaffolds for vascular tissue engineering in an animal model

BioMedical Engineering OnLine, 2017
Background The development of a suitable extracellular matrix (ECM) scaffold is the first step in vascular tissue engineering (VTE). Synthetic vascular grafts are available as an alternative to autologous vessels in large-diameter arteries (>8 mm) and ...
Shuangyue Xu, Fangna Lu, Lianna Cheng, Chenglin Li, Xu Zhou, Yuan Wu, Hongxing Chen, Kaichuang Zhang, Lumin Wang, Junjie Xia, Guoliang Yan, Zhongquan Qi   +11 more
doaj   +1 more source

Porcine anti-human lymphocyte immunoglobulin depletes the lymphocyte population to promote successful kidney transplantation

Frontiers in Immunology, 2023
IntroductionPorcine anti-human lymphocyte immunoglobulin (pALG) has been used in kidney transplantation, but its impacts on the lymphocyte cell pool remain unclear.MethodsWe retrospectively analyzed 12 kidney transplant recipients receiving pALG, and ...
Limin Zhang, Haoyong Zou, Xia Lu, Huibo Shi, Tao Xu, Shiqi Gu, Qinyu Yu, Wenqu Yin, Shi Chen, Zhi Zhang, Nianqiao Gong   +10 more
doaj   +1 more source

The relevance of EU directive 2010/53/EU for living organ donation practice [PDF]

, 2016
With the recent transposition of Directive 2010/53/EU into the transplant regulation of EU Member States, the time is right to have a closer look at its implications for living organ donation practice.
Burnapp, Lisa, Citterio, Franco, Dor, Frank, Frunza, Mihaela, Johnson, Rachel, Lennerling, Annette, Mamode, Nizam, Sterckx, Sigrid, Van Assche, Kristof, Weimar, Willem, Zuidema, Willij   +10 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Identification of ubiquitination-related signature genes for predicting kidney transplant rejection

Scientific Reports
Kidney transplant rejection (KTR) poses significant challenges to long-term graft survival, with involvement from ubiquitination-related genes (URGs) in immune modulation. This study aimed to identify key URGs linked to KTR and develop a predictive model
Zhengfei Shan, Shengqiang Yu, Jiantao Wang, Jianxin Cui, Haijian Wei, Xiaohua Fu, Chen Zhang, Chengjun Zhang   +7 more
doaj   +1 more source

ABO-incompatible living donor kidney transplantation failure due to acute blood group antibody-dependent rejection triggered by human parvovirus B19 infection: a case report and literature review

Frontiers in Medicine, 2023
BackgroundWith the improvement of immunosuppressive regimens, the success rate and availability of ABO-incompatible (ABO-i) kidney transplantation (KT) have gradually increased.
Lin-rui Dai, Xiao-hui Wang, Yi-bo Hou, Zhi-yu Zou, Song Chen, Wei-jie Zhang, Sheng Chang   +6 more
doaj   +1 more source

Cryopreservation of a whole liver [PDF]

, 2007
Preservation of vascularized organs such as the liver is limited to 24hrs. before destructive processes disqualify it for transplantation. This narrow time window prevents surgeons from performing optimal pathogen screening and matching tests which often
Amir Arav, Menahem Ben-Haim, Zohar Gavish   +2 more
core   +1 more source