Results 21 to 30 of about 1,167,376 (291)

Liraglutide Attenuates Hepatic Ischemia–Reperfusion Injury by Modulating Macrophage Polarization

Frontiers in Immunology, 2022
Ischemia-reperfusion injury (IRI) is a common complication associated with liver surgery, and macrophages play an important role in hepatic IRI. Liraglutide, a glucagon-like peptide-1 (GLP-1) analog primarily used to treat type 2 diabetes and obesity ...
Shang-Lin Li, Shang-Lin Li, Zhi-Min Wang, Cong Xu, Cong Xu, Fu-Heng Che, Fu-Heng Che, Xiao-Fan Hu, Xiao-Fan Hu, Rui Cao, Rui Cao, Ya-Nan Xie, Ya-Nan Xie, Yang Qiu, Yang Qiu, Hui-Bo Shi, Hui-Bo Shi, Bin Liu, Bin Liu, Chen Dai, Chen Dai, Jun Yang, Jun Yang   +22 more
doaj   +1 more source

Sirolimus in combination with low-dose extended-release tacrolimus in kidney transplant recipients

Frontiers in Medicine, 2023
IntroductionMany challenges remain for long-term survival of renal allografts. Once-daily sirolimus (SRL) combined with low-dose extended-release tacrolimus (LER-TAC) may improve medication adherence and reduce the potential nephrotoxicity of calcineurin
Zhi-yu Zou, Lin-rui Dai, Yi-bo Hou, Chen-zhen Yu, Ren-jie Chen, Yan-yan Chen, Bin Liu, Hui-bo Shi, Nian-qiao Gong, Zhi-shui Chen, Song Chen, Sheng Chang, Wei-jie Zhang   +12 more
doaj   +1 more source

Protocol TOP-Study (tacrolimus organ perfusion): a prospective randomized multicenter trial to reduce ischemia reperfusion injury in transplantation of marginal liver grafts with an "ex vivo" tacrolimus perfusion [PDF]

, 2013
Background: Critical organ shortage results in the utilization of extended donor criteria (EDC) liver grafts. These marginal liver grafts are prone to increased ischemia reperfusion injury (IRI) which may contribute to deteriorated graft function and ...
Jauch, Karl-Walter, Silvio Nadalin, Karl-Walter Jauch, Heise, Michael, Martin K Angele, Pratschke, Sebastian, Wolters, Heiner, Angele, Martin Kurt, Ulrich, Frank, Schemmer, Peter, Michael Heise, Dirk Wöhling, Angele, Martin K., Wöhling, Dirk, Sebastian Pratschke, Michael Eder, Nadalin, Silvio, Marcus N Scherer, Heiner Wolters, Andreas Pascher, Peter Schemmer, Scherer, Marcus N., Eder, Michael, Pascher, Andreas, Frank Ulrich   +24 more
core   +1 more source

Bone marrow derived mesenchymal stem cells pretreated with erythropoietin accelerate the repair of acute kidney injury

Cell & Bioscience, 2020
Background Mesenchymal stem cells (MSCs) represent a promising treatment option for acute kidney injury (AKI). The main drawbacks of MSCs therapy, including the lack of specific homing after systemic infusion and early cell death in the inflammatory ...
Song Zhou, Yu-ming Qiao, Yong-guang Liu, Ding Liu, Jian-min Hu, Jun Liao, Min Li, Ying Guo, Li-pei Fan, Liu-Yang Li, Ming Zhao   +10 more
doaj   +1 more source

When are bereaved family members approached for consent to organ donation? Commentary from 10 European member states [PDF]

, 2014
Background - To scope the timing of the approach to bereaved family members and request for organ donation in DBD and DCD potential donors, in 10 European member states. Are there changes in established practice regarding when family members are asked to
Long-Sutehall, Tracy, Jansen, Nichon, Sque, Magi, McDonald, Maryon, Haase-Kromwijk, Bernadette   +4 more
core   +2 more sources

In vivo therapeutic potential of Inula racemosa in hepatic ischemia–reperfusion injury following orthotopic liver transplantation in male albino rats

AMB Express, 2017
Hepatic ischemia–reperfusion (I/R) injury mainly occurs following hepatic resection and liver transplantation and cause severe liver damage, organ injuries, and dysfunction.
Zhuoyi Wang, Lei Geng, Zhiyun Chen, Bingyi Lin, Mangli Zhang, Shusen Zheng   +5 more
doaj   +1 more source

TJ-M2010-5, a novel CNS drug candidate, attenuates acute cerebral ischemia-reperfusion injury through the MyD88/NF-κB and ERK pathway

Frontiers in Pharmacology, 2022
Background: Cerebral ischemia-reperfusion injury (CIRI) inevitably occurs after vascular recanalization treatment for ischemic stroke. The accompanying inflammatory cascades have a major impact on outcome and regeneration after ischemic stroke. Evidences
Zeyang Li, Zeyang Li, Minghui Zhao, Minghui Zhao, Xiaoqian Zhang, Yiran Lu, Yang Yang, Yang Yang, Yalong Xie, Yalong Xie, Zhimiao Zou, Zhimiao Zou, Liang Zhou, Liang Zhou, Runshi Shang, Runshi Shang, Limin Zhang, Limin Zhang, Fengchao Jiang, Dunfeng Du, Dunfeng Du, Ping Zhou, Ping Zhou   +22 more
doaj   +1 more source

Heart transplantation: its risks, the expectations, and cultural negotiations in Japan [PDF]

, 2012
PhDThe aim of this thesis is to facilitate an understanding of the experiences of Japanese heart transplant recipients in terms of how their identities are transformed.
Tomomatsu, Ikuko
core   +4 more sources

Value of blood lipid in predicting graft dysfunction after organ and tissue transplantation: A study of Mendelian randomization

Heliyon, 2023
Background: While immunosuppressive regimens have improved outcomes in solid organ transplantation, non-immune factors have also been identified as contributors to graft prognosis.
Yuanyuan Zhao, Dunfeng Du, Lai Wei, Zhishui Chen   +3 more
doaj   +1 more source

Immunosuppression in Organ Transplantation

Japanese Journal of Pharmacology, 1996
The immunological barrier remains the major obstacle to the widespread use of transplantation as a replacement therapy for terminal organ failure. Since the first successful renal transplant, performed by Hume et al. (1952), there has been an elusive search for agents that can render the immune mechanism unresponsive to the specific alloantigen ...
Oka, Takahiro, Yoshimura, Norio
openaire   +3 more sources