Results 11 to 20 of about 248,910 (268)

In vivo therapeutic potential of Inula racemosa in hepatic ischemia–reperfusion injury following orthotopic liver transplantation in male albino rats

AMB Express, 2017
Hepatic ischemia–reperfusion (I/R) injury mainly occurs following hepatic resection and liver transplantation and cause severe liver damage, organ injuries, and dysfunction.
Zhuoyi Wang, Lei Geng, Zhiyun Chen, Bingyi Lin, Mangli Zhang, Shusen Zheng   +5 more
doaj   +1 more source

TJ-M2010-5, a novel CNS drug candidate, attenuates acute cerebral ischemia-reperfusion injury through the MyD88/NF-κB and ERK pathway

Frontiers in Pharmacology, 2022
Background: Cerebral ischemia-reperfusion injury (CIRI) inevitably occurs after vascular recanalization treatment for ischemic stroke. The accompanying inflammatory cascades have a major impact on outcome and regeneration after ischemic stroke. Evidences
Zeyang Li, Zeyang Li, Minghui Zhao, Minghui Zhao, Xiaoqian Zhang, Yiran Lu, Yang Yang, Yang Yang, Yalong Xie, Yalong Xie, Zhimiao Zou, Zhimiao Zou, Liang Zhou, Liang Zhou, Runshi Shang, Runshi Shang, Limin Zhang, Limin Zhang, Fengchao Jiang, Dunfeng Du, Dunfeng Du, Ping Zhou, Ping Zhou   +22 more
doaj   +1 more source

Value of blood lipid in predicting graft dysfunction after organ and tissue transplantation: A study of Mendelian randomization

Heliyon, 2023
Background: While immunosuppressive regimens have improved outcomes in solid organ transplantation, non-immune factors have also been identified as contributors to graft prognosis.
Yuanyuan Zhao, Dunfeng Du, Lai Wei, Zhishui Chen   +3 more
doaj   +1 more source

Shortage of organs for transplantation [PDF]

BMJ, 1996
Of all the problems foreseen in the pioneering days of organ transplantation, a shortage of donor organs was not even remotely considered as a barrier to progress. Such has been the success of transplantation over the past two decades that organ shortage is now considered the major limitation. This week sees the publication of an extensive study by the
C, Wight, B, Cohen
openaire   +2 more sources

Mapping trust relationships in organ donation and transplantation: a conceptual model

BMC Medical Ethics, 2023
The organ donation and transplantation (ODT) system heavily relies on the willingness of individuals to donate their organs. While it is widely believed that public trust plays a crucial role in shaping donation rates, the empirical support for this ...
María Victoria Martínez-López, Leah McLaughlin, Alberto Molina-Pérez, Krzysztof Pabisiak, Nadia Primc, Gurch Randhawa, David Rodríguez-Arias, Jorge Suárez, Sabine Wöhlke, Janet Delgado   +9 more
doaj   +1 more source

Immunosuppression in Organ Transplantation

Japanese Journal of Pharmacology, 1996
The immunological barrier remains the major obstacle to the widespread use of transplantation as a replacement therapy for terminal organ failure. Since the first successful renal transplant, performed by Hume et al. (1952), there has been an elusive search for agents that can render the immune mechanism unresponsive to the specific alloantigen ...
Oka, Takahiro, Yoshimura, Norio
openaire   +3 more sources

Macrophages in Organ Transplantation [PDF]

Frontiers in Immunology, 2020
Current immunosuppressive therapy has led to excellent short-term survival rates in organ transplantation. However, long-term graft survival rates are suboptimal, and a vast number of allografts are gradually lost in the clinic. An increasing number of animal and clinical studies have demonstrated that monocytes and macrophages play a pivotal role in ...
Farideh Ordikhani, Venu Pothula, Rodrigo Sanchez-Tarjuelo, Stefan Jordan, Jordi Ochando, Jordi Ochando   +5 more
openaire   +4 more sources

Heme oxygenase-1-transduced bone marrow mesenchymal stem cells in reducing acute rejection and improving small bowel transplantation outcomes in rats

Stem Cell Research & Therapy, 2016
Background We determined whether bone marrow mesenchymal stem cells (BMMSCs) transduced with heme oxygenase-1 (HO-1), a cytoprotective and immune-protective factor, could improve outcomes for small bowel transplantation (SBTx) in rats.
Yang Yang, Hong Li Song, Wen Zhang, Ben Juan Wu, Nan Nan Fu, Chong Dong, Zhong Yang Shen   +6 more
doaj   +1 more source

Identification of the Subtypes of Renal Ischemia-Reperfusion Injury Based on Pyroptosis-Related Genes

Biomolecules, 2023
Ischemia-reperfusion injury (IRI) often occurs in the process of kidney transplantation, which significantly impacts the subsequent treatment and prognosis of patients.
Xinhao Niu, Yin Celeste Cheuk, Xiao Li, Ruiming Rong, Xiaoqing Xu, Cuidi Xu, Yongsheng Luo, Pingbao Zhang, Jingjing Guo   +8 more
doaj   +1 more source

Are Fertility Preservation Procedures Before Gonadotoxic Therapy and Hematopoietic Stem Cell Transplantation Feasible and Safe in Very Young Children? A Retrospective Cohort Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Fertility preservation (FP) is increasingly integrated into the care of pediatric patients exposed to gonadotoxic therapy or conditioning for hematopoietic stem cell transplantation (HSCT), yet perioperative data in infants and toddlers remain scarce.
Kerstin Saalabian, Yannick Braun, Till‐Martin Theilen, Anke Barnbrock, Theresa Rohm, Fabienne Hammant, Nicole Sänger, Aynura Abbasova‐Semiz, Jan‐Henning Klusmann, Thomas Klingebiel, Udo Rolle, Peter Bader, Henning C. Fiegel, Andrea Jarisch   +13 more
wiley   +1 more source