Results 51 to 60 of about 286,304 (317)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Impact of music on pain perception during office-based transperineal prostate biopsy: a prospective non-randomized study

Scientific Reports
Although music has been shown to alleviate pain and anxiety during transrectal PBx, limited evidence is available regarding its impact in the transperineal (TP) setting. This study aimed to investigate the effect of music on pain perception during office-
Luca Montrone, Marco Finati, Anna Ricapito, Antonio Fanelli, Nicolò Giannoccaro, Francesco Troiano, Giuliano Ciavotta, Ugo Giovanni Falagario, Luigi Cormio, Gian Maria Busetto, Carlo Bettocchi, Oscar Selvaggio, Giuseppe Carrieri   +12 more
doaj   +1 more source

Sirtuin 3 in renal diseases and aging: From mechanisms to potential therapies

Pharmacological Research
The longevity protein sirtuins (SIRTs) belong to a family of nicotinamide adenine dinucleotide (NAD+)-dependent deacetylases. In mammals, SIRTs comprise seven members (SIRT1–7) which are localized to different subcellular compartments.
Xuan Peng, Haiqiang Ni, Baicheng Kuang, Zhiheng Wang, Shuaiheng Hou, Shiqi Gu, Nianqiao Gong   +6 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Extended pancreas donor program - the EXPAND study rationale and study protocol [PDF]

, 2013
BACKGROUND: Simultaneous pancreas kidney transplantation (SPK), pancreas transplantation alone (PTA) or pancreas transplantation after kidney (PAK) are the only curative treatment options for patients with type 1 (juvenile) diabetes mellitus with or ...
Bechstein, Wolf Otto, Carsten Dietz, Falk Rauchfuss, Holub, Ines, Peter Schenker, Heise, Michael, Volker Müller, Rauchfuss, Falk, Proneth, Andrea, Florian Zeman, Björn Nashan, Markus Guba, Banas, Bernhard, Stefan Thorban, Schemmer, Peter, Edward K Geissler, Stephan Kersting, Ströhlein, Michael A., Andreas A Schnitzbauer, Nashan, Björn, Jonas, Sven, Thomas Becker, Ines Holub, Johanna R Foerster, Andreas Pascher, Manekeller, Steffen, Viebahn, Richard, Müller, Volker, Thomas Vogel, Peter Schemmer, Bernhard Banas, Farkas, Stefan A., Andrea Proneth, Arbogast, Helmut, Schenker, Peter, Richard Viebahn, Thorban, Stefan, Jürgen Klempnauer, Silvio Nadalin, Axel O Rahmel, Vogel, Thomas, Becker, Thomas, Guba, Markus, Zeman, Florian, Kersting, Stephan, Michael Heise, Rahmel, Axel, Klempnauer, Jürgen, Schlitt, Hans J., Schnitzbauer, Andreas, Stefan A Farkas, Nadalin, Silvio, Sven Jonas, Steffen Manekeller, Helmut Arbogast, Hans J Schlitt, Dietz, Carsten, Michael A Ströhlein, Geissler, Edward K., Wolf O Bechstein, Foerster, Johanna R., Pascher, Andreas, Andrea Proneth   +62 more
core   +1 more source

Organ Transplantation in Argentina

Transplantation, 2018
Argentina is a federal republic located in the southern portion of South America, with a mainland area of 2 780 400 km2. Argentina is the eighth largest country in the world, and the second largest in Latin America. Spanish is the main language; the population has been estimated at 43 847 430 in 2016, (Figure 1).
Gondolesi, Gabriel Eduardo, Bisigniano, Liliana, Bertolotti, Alejandro Mario, Barros Schelotto, Pablo, Raffaele, Pablo   +4 more
openaire   +4 more sources

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Longitudinal profiling of gut microbiota dynamics in kidney transplant recipients

Journal of Translational Medicine
Background The gut microbiota undergoes substantial alterations in kidney transplant recipients, which are linked to postoperative complications and renal function recovery. However, the underlying mechanisms of these associations remain unclear. Methods
Weibo Zhong, Runtao Feng, Haoxin Liang, Jianmin Hu, Song Zhou, Ding Liu, Shichao Li, Guorong Liao, Jun Liao, Siqiang Yang, Ya Zhang, Xinyun Xiao, Jun Qian, Hua Chen, Lipei Fan, Min Li, Ming Zhao, Jianrong Chen, Yongguang Liu   +18 more
doaj   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

Daratumumab followed by tocilizumab for treatment of late antibody-mediated rejection in renal transplant recipients with high or moderate levels of de novo donor-specific antibodies: a pilot study

BMC Nephrology
Background Effective treatment of late antibody-mediated rejection (late AMR) is still an unmet medical need. Clearing donor-specific antibody (DSA) and preventing its rebound is the ideal goal of treatment.
Zhiliang Guo, Rula Sa, Daqiang Zhao, Songxia Li, Hui Guo, Lan Zhu, Gang Chen   +6 more
doaj   +1 more source