Results 81 to 90 of about 248,774 (310)

SF3B4 regulates proliferation and apoptosis in hepatocellular carcinoma via alternative splicing and interaction with TRIM28 and SETD5

open access: yesJournal of Translational Medicine
Background SF3B4 encodes a core subunit of the U2-type spliceosome and is implicated in abnormal cell growth and tumorigenesis. However, its role in regulating gene expression and alternative splicing in hepatocellular carcinoma (HCC) remains ...
HanFei Huang   +9 more
doaj   +1 more source

Nanobody‐Decorated Lipid Nanoparticles for Enhanced mRNA Delivery to Tumors In Vivo

open access: yesAdvanced Healthcare Materials, EarlyView.
This study presents a targeted mRNA‐LNP platform engineered with anti‐PSMA nanobodies for prostate cancer therapy. Using different in vivo models, the authors demonstrate selective uptake and mRNA delivery in PSMA+ cancer cells. However, while targeting is enhanced, mRNA delivery efficacy is limited by tissue penetration, tumor necrosis, and immune ...
Pol Escudé Martinez de Castilla   +16 more
wiley   +1 more source

Low proportion of follicular regulatory T cell in renal transplant patients with chronic antibody-mediated rejection

open access: yesScientific Reports, 2017
Follicular regulatory T (Tfr) cell can effectively regulate humoral immunity, but its function and mechanism in antibody-mediated rejection (AMR) after organ transplantation remains unclear.
Wen Chen   +8 more
doaj   +1 more source

Photocrosslinkable Kidney Decellularized Extracellular Matrix‐Based Bioink for 3D Bioprinting

open access: yesAdvanced Healthcare Materials, EarlyView.
A photocrosslinkable bioink is developed from methacrylated decellularized porcine kidney extracellular matrix to create kidney‐specific 3D constructs. This bioink supports high cell viability, promotes multicellular spheroid formation, and enables stable multilayer bioprinting with tunable mechanical properties, providing a versatile platform for ...
Jaemyung Shin   +5 more
wiley   +1 more source

Causal relationship between primary sclerosing cholangitis and systemic lupus erythematosus: a bidirectional Mendelian randomization study

open access: yesEuropean Journal of Medical Research
Background Observational studies have found a link between two autoimmune diseases, namely, primary sclerosing cholangitis (PSC) and systemic lupus erythematosus (SLE). However, the relationship remains unclear.
Ziwen Pan, Weijie Zhang
doaj   +1 more source

Clinical Experience With Organ Transplantation [PDF]

open access: green, 1965
Thomas E. Starzl   +4 more
openalex   +1 more source

Human Skin Models in Biophotonics: Materials, Methods, and Applications

open access: yesAdvanced Healthcare Materials, EarlyView.
This review discusses how the optical properties of human skin can be replicated in human skin models. It describes the principles, materials, and techniques used to develop artificial skin for biophotonics research. Finally, the article highlights recent advances and shows how these models improve the study of light‐skin interactions without the need ...
Dardan Bajrami   +4 more
wiley   +1 more source

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