Results 91 to 100 of about 286,304 (317)

Microfabricated Anisotropic Myobundles for the Scalable Production of Cardiac Tissue Grafts

Advanced Functional Materials, EarlyView.
Controlling the anisotropy of cardiac tissue remains an outstanding challenge in the field of cardiac tissue engineering. Here, we introduce an approach to generate anisotropic cardiac myobundles using cell‐adhesive, synthetic, electrospun fibers and stem cell‐derived cardiac fibroblasts.
Maggie E. Jewett, Javiera Jilberto, Margaret E. Stanley, David O. Ntim, Siddhi M. Bhirud, Avianna T. Schroeder, Gonzola X. Anyosa Galvez, Jingyi Xia, Samuel J. DePalma, Emmanouil Agrafiotis, Susan S. Xi, Amanda S. Bluem, Courtney M. Lestock, Adam S. Helms, David A. Nordsletten, Brendon M. Baker   +15 more
wiley   +1 more source

Transplant arteriosclerosis : an experimental study on risk factors and pathogenetic mechanisms [PDF]

, 2001
In this thesis, we focused on vascular damage inflicted after transplantation, i.e. injury of the graft vasculature as a result of an alloreactive response of the host against the graft, and everal factors in-fluencing this process.
Hillebrands, Jan Lucas, Hillebrands, Jan Lucas,, Hillebrands, Jan Lucas; id_orcid   +2 more
core  

Perspectives in organ preservation.

, 2007
Maintaining organ viability after donation until transplantation is critically important for optimal graft function and survival. To date, static cold storage is the most widely used form of preservation in every day clinical practice.
Henri G. D. Leuvenink, Leuvenink, Henri G. D.; id_orcid, Ploeg, Rutger, Rutger J. Ploeg, Leuvenink, Henri G. D., Maathuis, MH, Mark-Hugo J. Maathuis, Leuvenink, HG, Maathuis, Mark-Hugo J., Ploeg, Rutger J., Ploeg, RJ   +10 more
core   +1 more source

Helminths and immunological tolerance [PDF]

, 2014
Current immunosuppression regimens for solid-organ transplantation have shown disappointing efficacy in the prevention of chronic allograft rejection and carry unacceptable risks including toxicity, neoplasia, and life-threatening infection.
McSorley, Henry J., Maizels, Rick M., Maizels, Rick M, Johnston, Chris J C, Wigmore, Stephen J, Johnston, Chris J.C., Wigmore, Stephen J., Anderton, Stephen M, McSorley, Henry J, Anderton, Stephen M., Johnston, Chris J. C., McSorley, Henry J.; id_orcid   +11 more
core   +1 more source

Translational Considerations for Injectable Biomaterials and Bioscaffolds to Repair and Regenerate Brain Tissue

Advanced Healthcare Materials, EarlyView.
The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley   +1 more source

Towards Personalized Tacrolimus Dosing Using an Algorithm-Driven Prediction Pipeline for Kidney Transplant

Drug Design, Development and Therapy
Jianliang Min,1– 3,* Qihao Li,1,3,* Weijie Lai,1,3,* Zi Liu,4 Guodong Chen1,3 1Department of Organ Transplantation Center, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, People’s Republic of China; 2School of ...
Min J, Li Q, Lai W, Liu Z, Chen G
doaj  

Bioethics of Organ Transplantation [PDF]

Cold Spring Harbor Perspectives in Medicine, 2014
As the ability to transplant organs and tissues has grown, the demand for these procedures has increased as well--to the point at which it far exceeds the available supply creating the core ethical challenge for transplantation--rationing. The gap between supply and demand, although large, is worse than it appears to be.
openaire   +2 more sources

Coaxially Electrospun Myocardial dECM‐ Based Nanofibrous Scaffolds Demonstrate Enhanced Cardiomyocyte Biocompatibility

Advanced Healthcare Materials, EarlyView.
Our coaxial electrospinning system is capable of incorporating decellularized myocardial extracellular matrix in a core‐sheath configuration, creating nanofibrous scaffolds. These scaffolds, in turn, support the maintenance of functional cardiomyocytes adhered to the surface of these bioactive scaffolds.
Dhanusha N. Rajapakse, Mahtab Khodadadi, Kiran M. Ali, Suh Hee Cook, Bryson T. Proctor, Tanya Upadhyay, Daxian Zha, Fatema Tuj Jahura, Marziyeh Boosaliki, Jessica M. Gluck   +9 more
wiley   +1 more source

The need for increasing the retrieval of organs : doctors’ attitudes towards opting-out [PDF]

, 2010
Some countries have introduced the opting-out system of organ donation as a way of increasing the number of available organs for transplants. Public opinion is divided on this issue and so are medical recommendations.
Lauri, Mary Anne, Zarb Adami, Joseph
core  

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, EarlyView.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source