Results 111 to 120 of about 1,167,376 (291)

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Pentraxin-3 modulates hepatocyte ferroptosis and the innate immune response in LPS-induced liver injury

Molecular Biomedicine
The liver plays a crucial role in the immune response during endotoxemia and is one of the critical targets for sepsis-related injuries. As a secretory factor involved in inflammation, pentraxin-3 (PTX3) has been demonstrated to regulate hepatic ...
Huitong Wang, Zhaojie Su, Yunyun Qian, Baojie Shi, Hao Li, Wenbin An, Yi Xiao, Cheng Qiu, Zhixiang Guo, Jianfa Zhong, Xia Wu, Jiajia Chen, Ying Wang, Wei Zeng, Linghui Zhan, Jie Wang   +15 more
doaj   +1 more source

Methyl eugenol attenuates age-associated oxidative fragility by coupling Ca2+-calpain inhibition with Band 3 stabilization in human erythrocytes

Frontiers in Physiology
BackgroundHuman erythrocytes serve as an ideal model for cellular aging, a process where longevity relies on membrane scaffold integrity. The oxidative deterioration of Band 3, a major integral membrane protein, is a central driver of this senescence ...
Jiasi Zhang, Jiasi Zhang, Qingwen Li, Yilan Dai, Shuaiheng Hou, Xuan Peng, Ji Zhang, Ji Zhang, Nianqiao Gong   +8 more
doaj   +1 more source

Kidney Transplantation: Strategies to Prevent Organ Rejection /

, 2005
Transplantation is today firmly established as the therapy of choice for end-stage organ failure. However, despite recent developments, this therapy is still not without challenges and risks: The necessity to take immunosuppressive drugs for the rest of ...
Ronco, C.
core  

Transplant arteriosclerosis : an experimental study on risk factors and pathogenetic mechanisms [PDF]

, 2001
In this thesis, we focused on vascular damage inflicted after transplantation, i.e. injury of the graft vasculature as a result of an alloreactive response of the host against the graft, and everal factors in-fluencing this process.
Hillebrands, Jan Lucas, Hillebrands, Jan Lucas,, Hillebrands, Jan Lucas; id_orcid   +2 more
core   +17 more sources

A Soft, Flexible Implant for Wireless Photothermal–Pyroelectric Neurostimulation

Advanced Science, EarlyView.
A replication strategy is used to enlarge the exposed surface area of barium titanate within flexible films with embedded carbon nanotubes, enabling efficient photothermal‐pyroelectric stimulation. Polar crystalline nanosheets show superior performance in guiding neural progenitor cells toward neuronal differentiation.
Jiang Wu, Minmin Mao, Beltzane Garcia Cirera, Hao Ye, Xiangzhong Chen, Josep Puigmartí‐Luis, Ni Qin, Salvador Pané   +7 more
wiley   +1 more source

Competition and Post-Transplant Outcomes in Cadaveric Liver Transplantation under the MELD Scoring System [PDF]

Previous researchers have modelled the decision to accept a donor organ for transplantation as a Markov decision problem, the solution to which is often a control-limit optimal policy: accept any organ whose match quality exceeds some health-dependent ...
Alberto M. Segre, Jeffrey B. Halldorson, John P. Roberts, Harry J. Paarsch   +3 more
core   +2 more sources

Rethinking Proteinuria: Resolution of Donor Derived EXT2-Associated Membranous Nephropathy Following Renal Transplantation

Case Reports in Transplantation
Exostosin-2 (EXT2)-associated membranous nephropathy (MN) represents a subgroup of immune complex-mediated renal diseases, where transplantation may facilitate clearance of immune deposits.
Mike Fruscione, Devarsh Desai, Satoru Kudose, Yasir Qazi, Samuel Sultan, Kenneth Lieberman, Michael J. Goldstein   +6 more
doaj   +1 more source

Overcoming the problem of cytomegalovirus infection after organ transplantation: Calling for Heracles?

, 1999
Although diagnosis of CMV infections and treatment of CMV disease with effective antiviral drugs have become much easier, the persistent problem of CMV infection after solid-organ transplantation still requires solid knowledge of the patho physiology of ...
van Son, WJ, Verschuuren, EAM, van den Berg, AP, Verschuuren, EAM; id_orcid, de Maar, EF, van der Bij, W, The, TH   +6 more
core  

Perspectives in organ preservation.

, 2007
Maintaining organ viability after donation until transplantation is critically important for optimal graft function and survival. To date, static cold storage is the most widely used form of preservation in every day clinical practice.
Henri G. D. Leuvenink, Leuvenink, Henri G. D.; id_orcid, Ploeg, Rutger, Rutger J. Ploeg, Leuvenink, Henri G. D., Maathuis, MH, Mark-Hugo J. Maathuis, Leuvenink, HG, Maathuis, Mark-Hugo J., Ploeg, Rutger J., Ploeg, RJ   +10 more
core   +1 more source