Results 111 to 120 of about 1,082,916 (254)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Predictive Modeling for Inactivation of Escherichia coli Biofilm with Combined Treatment of Thermosonication and Organic Acid on Polystyrene Surface

Foods
The present study aimed to evaluate the antibiofilm effect of combined sonication treatment with organic acids on polystyrene surfaces and to develop a predictive model for the inactivation of Escherichia coli biofilms.
Emel Unal Turhan, Esabil Emrah Koca
doaj   +1 more source

Geschmack- und gesundheitsrelevante Qualität von ökologisch angbauten Äpfeln: Eine 3jährige Feldvergleichsstudie mit standard- und ganzheitlichen Untersuchungsmethoden [PDF]

, 2004
In a 3 years lasting field study with the ‘Golden Delicious’ cultivar, we compared fruits of 5 pairs of organic/integrated fruit farms. The orchards were similar in microclimate, soil conditions and planting system.
Graf, Ursula, Häseli, Andi, Treutter, Dieter, Weibel, Franco P.   +3 more
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Metabolomics Study by Amino and Organic Acid Profiling Analyses in Pre- and Post-Milling Barley Using Gas Chromatography-Tandem Mass Spectrometry

Crops
Barley (Hordeum vulgare) is a major cereal grain grown in temperate climates globally and provides various nutrients in a peeled form after milling. However, milling causes changes in nutritional composition, including metabolites.
Byeongchan Choi, Moongi Ji, Songjin Oh, Jaeyeop Lim, Mi Ja Lee, Man-Jeong Paik   +5 more
doaj   +1 more source

A new parametrization for ambient particle formation over coniferous forests and its potential implications for the future [PDF]

, 2009
Atmospheric new particle formation is a general phenomenon observed over coniferous forests. So far nucleation is either parameterised as a function of gaseous sulphuric acid concentration only, which is unable to explain the observed seasonality of ...
Bonn, Boris, Borchert, Sebastian, Boy, Michael, Groth, Angela, Jacobi, Stefan, Kulmala, Markku, Trawny, Katrin   +6 more
core  

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Laxative Effect of Glutinous Rice Banana Enzyme on Constipated Mice

Shipin gongye ke-ji
Objective: Exploring the laxative and intestinal protective effects of glutinous rice banana enzyme (GRBE) on constipated mice. Methods: A mouse constipation model was established by administering loperamide hydrochloride (LH).
Lilang LI, Sha LIU, Donghai LI, Zhaoju ZHANG, Xiaosheng YANG, Juan YANG, Zhengrong ZHANG, Fufei ZENG, Yu WANG   +8 more
doaj   +1 more source

Adsorption and desorption dynamics of citric acid anions in soil [PDF]

, 2010
The functional role of organic acid anions (e.g. citrate, oxalate, malonate, etc) in soil has been intensively investigated with special focus either on (i) microbial respiration and soil carbon dynamics, (ii) nutrient solubilization, or (iii) metal ...
Jones, D. L., Leitner, D., Oburger, E., Roose, T., Schnepf, A., Zygalakis, K. C.   +5 more
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source