Delivering anion transporters to lipid bilayers in water [PDF]
, 2021 Cyclodextrins have been employed as delivery agents for lipophilic anion transporters, which allow their incorporation into lipid bilayers without using an organic solvent or pre ...
To, Tsz Ying (Teresa) +9 more
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Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations [PDF]
, 2021 Membrane transporters are of vital importance for cells. They mediate the flux of many substances through the plasma membrane. In this book, the transporters for organic cations, a special class of membrane transporters, are presented.
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Characterization of an organic anion-transporting polypeptide (OATP-B) in human placenta [PDF]
, 2002 Organic anion-transporting polypeptides (OATPs) are a family of multispecific carriers that mediate the sodium-independent transport of steroid hormone and conjugates, drugs, and numerous anionic endogenous substrates.
Stallmach, T. +4 more
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Characterisation and validation of drug transport and GLP-1R function in primary porcine proximal tubular cells [PDF]
, 2006 Overview kidney: Kidney is, beside the liver, one of the most important organs for the elimination of waste products, toxins, drugs and their metabolites. Due to the anatomy of the kidney, ultra filtrate leaving the glomerulus passes first the proximal
Schlatter, Philipp
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Identification of steroid sulfate transport processes in the human mammary gland [PDF]
, 2003 Circulating hormones and local biotransformation of steroid precursors are both sources of estrogen in human mammary tissue. Estrone-3-sulfate (E(1)S) is an important estrogenic form in premenopausal women, and dehydroepiandrosterone sulfate (DHEAS ...
Pizzagalli, F. +5 more
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Prediction of human drug clearance and anticipation of clinical drug-drug interaction potential from in vitro drug transport studies [PDF]
, 2014 A major concern in drug development is the characterization of new molecular entities (NMEs) with respect to their safety and efficacy. Both factors are determined by the drug’s exposure within the body which itself is affected by drug clearance ...
Kunze, Annett
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Expression of drug transporters in intestine and blood [PDF]
, 2005 Proteins that are capable to transport molecules across membranes are fundamental for the accurate functioning of the body. Many diseases have their cause in a dysfunction of a particular transport protein.
Zimmermann, Christian
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Comparison of human hepatoma HepaRG cells with human and rat hepatocytes in uptake transport assays in order to predict drug induced hepatotoxicity [PDF]
, 2013 Human hepatocytes are the gold standard for toxicological studies but they have several drawbacks, like scarce availability, high inter-individual variability, a short lifetime, which limits their applicability.
Jemnitz, Katalin +9 more
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Tetrapodal Anion Transporters [PDF]
, 2020 Synthetic anion transporters that facilitate chloride transport are promising candidates for channelopathy treatments. However, most anion transporters exhibit an undesired side effect of facilitating proton transport via interacting with fatty acids ...
Lijun Chen +13 more
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Characterization of Novel Fluorescent Bile Salt Derivatives for Studying Human Bile Salt and Organic Anion Transporters [PDF]
, 2021 Bile salts such as cholate, glycocholate, taurocholate and glycochenodeoxycholate are taken up from the portal blood into hepatocytes via transporters such as the Na+-taurocholate cotransporting polypeptide (NTCP) and organic anion transporting ...
Hausler, Stephanie +6 more
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