Results 41 to 50 of about 1,562,945 (312)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Low‐Cost, High‐Efficiency Organic Solar Cells Based on Ecofriendly Processing Solvent

Advanced Energy & Sustainability Research
Developing organic photovoltaic materials at low‐cost and processing with eco‐friendly solvents are promising strategies to solve the critical issues of organic photovoltaic. Key hurdles for commercialization are synthetic complexity of the donor and the
Yunpeng Qin, Haoran Tu, Nathan Woodward, Mihirsinh Chauhan, Gaurab J. Thapa, Aram Amassian, Justin Neuf, Wei You, Haipeng Yin, Harald Ade   +9 more
doaj   +1 more source

Dutch (organic) agriculture, carbon sequestration and energy production [PDF]

, 2008
Carbon sequestration in soils is often mentioned in the discussions about climate changes. In this paper the opportunities for carbon sequestration in Dutch agriculture are discussed at farm and national level.
Staps, Ing. J.J.M., Timmermans, Dr. B.G.H., van der Burgt, Ir. G.J.H.M.   +2 more
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Stable pure-green organic light-emitting diodes toward Rec.2020 standard

Nature Communications
Manipulating dynamic behaviours of charge carriers and excitons in organic light-emitting diodes (OLEDs) is essential to simultaneously achieve high colour purity and superior operational lifetime.
Xun Tang, Tuul Tsagaantsooj, Tharindu P. B. Rajakaruna, Kai Wang, Xian-Kai Chen, Xiao-Hong Zhang, Takuji Hatakeyama, Chihaya Adachi   +7 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Accurate single-shot full-Stokes detection enabled by heterogeneous grain orientations in polycrystalline films

Nature Communications
Decoding arbitrary polarization information in a cost-effective way is a key target for next-generation optical sensing. However, the design of full-Stokes detectors capable of resolving polarization states in a single shot remains challenging.
Mingwei Ge, Yuan Yao, Tyler Wang, Subhrangsu Mukherjee, Harald Ade, Mengxia Liu   +5 more
doaj   +1 more source

8-Hydroxyquinoline Glycoconjugates: Modifications in the Linker Structure and Their Effect on the Cytotoxicity of the Obtained Compounds

Molecules, 2019
Small molecule nitrogen heterocycles are very important structures, widely used in the design of potential pharmaceuticals. Particularly, derivatives of 8-hydroxyquinoline (8-HQ) are successfully used to design promising anti-cancer agents. Conjugating 8-
Monika Krawczyk, Gabriela Pastuch-Gawołek, Aleksandra Pluta, Karol Erfurt, Adrian Domiński, Piotr Kurcok   +5 more
doaj   +1 more source

Soil fertility comparison among organic and conventional managed citrus orchards in Sicily. [PDF]

, 2002
In recents years, organic farming is expanding in Southern Italy and in the Mediterranean area, due to interest of consumers and EU agricultural policies.
Alessandra, Dr. Trinchera, Anna, Dr. Benedetti, Emanuela, Dr. Di Bartolomeo, Francesco, Dr. Intrigliolo, Luigi, Dr. Nisini, Stefano, Dr. Canali   +5 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source