Results 71 to 80 of about 1,586,299 (311)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

The role of interfacial donor–acceptor percolation in efficient and stable all-polymer solar cells

Nature Communications
Polymerization of Y6-type acceptor molecules leads to bulk-heterojunction organic solar cells with both high power-conversion efficiency and device stability, but the underlying mechanism remains unclear.
Zhen Wang, Yu Guo, Xianzhao Liu, Wenchao Shu, Guangchao Han, Kan Ding, Subhrangsu Mukherjee, Nan Zhang, Hin-Lap Yip, Yuanping Yi, Harald Ade, Philip C. Y. Chow   +11 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Synthesis of benzoheterocycles by palladium-catalyzed migratory cyclization through an unexpected reaction cascade

Nature Communications
Migratory functionalization of C–H bonds through metal migration from carbon to carbon under transition metal catalysis is a process of significant academic and industrial interest.
Wen-Cong Li, Lin Zhang, Shiming Bai, Jia-Hao Zhao, Guang-Rui Liu, Yu Lan, Shufeng Chen, Jialin Ming   +7 more
doaj   +1 more source

Removal of disinfection by-product precursors by coagulation and an innovative suspended ion exchange process [PDF]

, 2015
This investigation aimed to compare the disinfection by-product formation potentials (DBPFPs) of three UK surface waters (1 upland reservoir and 2 lowland rivers) with differing characteristics treated by (a) a full scale conventional process and (b ...
Jarvis, Peter, Jefferson, Bruce, Judd, Simon J., Metcalfe, David, Rockey, Chris   +4 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

L‐Cysteine‐Encapsulated MXene Nanosheet Possessing Ultra‐Antioxidation in Aqueous Suspension for Electrophoretic Deposition Assisted Carbon‐Fiber‐Surface Modification

Advanced Materials Interfaces
With recent progress in 2D materials, Ti3C2Tx MXene featured high metallic electrical conductivity, high electromagnetic interference shielding effectiveness, and super in‐plane stiffness, exhibits unique advantages in many fields, but is rarely applied ...
Ling Huang, Zheyuan Du, Yanhong Tian, Jiangman Sun, Jinglong Li, Yue Xing, Xiubing Liang, Xuejun Zhang   +7 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Cathode Electrolyte Interphase Engineering by Quaternized Chitosan for Stabilized Li–SPAN Batteries

Advanced Science
Sulfurized polyacrylonitrile (SPAN) represents a highly promising cathode material for lithium–sulfur (Li–S) batteries, leveraging a solid‐solid sulfur conversion mechanism.
Runhe He, Hao Liu, Qing Gao, Dong Cai, Kuikui Xiao, Yinhang Zhang, Xinmin Zhang, Xianyang Cheng, Yuhui Wang, Lixing Kang, Huagui Nie, Yatao Liu, Zhi Yang   +12 more
doaj   +1 more source

Farmyard manure, plant based organic fertilisers, inorganic fertiliser - which sustains soil organic matter best? [PDF]

, 2006
Legume biomass or pulse meal may be considered as alternatives to farmyard manure (FYM) in organic farms with small scale animal husbandry or in stockless organic farms.
Oltmanns, Meike, Raupp, Joachim
core