Results 151 to 160 of about 108,823 (192)

The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations

Trends in Pharmacological Sciences, 2006
Multidrug and toxic compound extrusion (MATE) proteins, comprising the most recently designated family of multidrug transporter proteins, are widely distributed in all kingdoms of living organisms, although their function is far from understood. The bacterial MATE-type transporters that have been characterized function as exporters of cationic drugs ...
Hiroshi, Omote, Miki, Hiasa, Takuya, Matsumoto, Masato, Otsuka, Yoshinori, Moriyama   +4 more
openaire   +2 more sources

Transport of asymmetric dimethylarginine (ADMA) by cationic amino acid transporter 2 (CAT2), organic cation transporter 2 (OCT2) and multidrug and toxin extrusion protein 1 (MATE1)

Amino Acids, 2013
Asymmetric dimethylarginine (ADMA), inhibiting the nitric oxide (NO) synthesis from L-arginine, is a known cardiovascular risk factor. Our aim was to investigate if ADMA and/or L-arginine are substrates of the human cationic amino acid transporters 2A (CAT2A, SLC7A2A) and 2B (CAT2B, SLC7A2B), the organic cation transporter 2 (OCT2, SLC22A2), and the ...
Joachim, Strobel, Fabian, Müller, Oliver, Zolk, Beate, Endreß, Jörg, König, Martin F, Fromm, Renke, Maas   +6 more
openaire   +2 more sources

Functional effects of protein sequence polymorphisms in the organic cation/ergothioneine transporter OCTN1 (SLC22A4)

Pharmacogenetics and Genomics, 2007
OCTN1 is a multispecific transporter of organic cations and zwitterions, including several clinically important drugs as well as the antioxidant ergothioneine. OCTN1 is highly expressed in the kidney, where it is thought to aid in active secretion of organic cations, and may facilitate the active reabsorption of ergothioneine.
Thomas J, Urban, Chen, Yang, Leah L, Lagpacan, Chaline, Brown, Richard A, Castro, Travis R, Taylor, Conrad C, Huang, Douglas, Stryke, Susan J, Johns, Michiko, Kawamoto, Elaine J, Carlson, Thomas E, Ferrin, Esteban G, Burchard, Kathleen M, Giacomini   +13 more
openaire   +2 more sources

PDZ Adaptor Protein PDZK2 Stimulates Transport Activity of Organic Cation/Carnitine Transporter OCTN2 by Modulating Cell Surface Expression

Drug Metabolism and Disposition, 2006
A part of the organic cation transporter families (OCT3, OCTN1, and OCTN2) has recently been identified to physically interact with PDZ (PSD95, Dlg, and ZO1) domain-containing proteins, although the physiological relevance of such interaction has not yet been fully examined.
Chizuru, Watanabe, Yukio, Kato, Tomoko, Sugiura, Yoshiyuki, Kubo, Tomohiko, Wakayama, Shoichi, Iseki, Akira, Tsuji   +6 more
openaire   +2 more sources

Structural Requirements for Drug Inhibition of the Liver Specific Human Organic Cation Transport Protein 1

Journal of Medicinal Chemistry, 2008
The liver-specific organic cation transport protein (OCT1; SLC22A1) transports several cationic drugs including the antidiabetic drug metformin and the anticancer agents oxaliplatin and imatinib. In this study, we explored the chemical space of registered oral drugs with the aim of studying the inhibition pattern of OCT1 and of developing predictive ...
Gustav, Ahlin, Johan, Karlsson, Jenny M, Pedersen, Lena, Gustavsson, Rolf, Larsson, Pär, Matsson, Ulf, Norinder, Christel A S, Bergström, Per, Artursson   +8 more
openaire   +2 more sources

Studies on Functional Sites of Organic Cation/Carnitine Transporter OCTN2 (SLC22A5) Using a Ser467Cys Mutant Protein

The Journal of Pharmacology and Experimental Therapeutics, 2002
The organic cation/carnitine transporter OCTN2 mediates transport of carnitine and organic cations in Na(+)-dependent and Na(+)-independent manners, respectively. However, the mechanism of molecular recognition of different substrates has not been clarified yet. We previously found a single amino acid change in OCTN2, Ser467Cys (S467C), in the Japanese
Rikiya, Ohashi, Ikumi, Tamai, Akihiro, Inano, Masaki, Katsura, Yoshimichi, Sai, Jun-ichi, Nezu, Akira, Tsuji   +6 more
openaire   +2 more sources

Protein kinase inhibition differentially regulates organic cation transport.

Canadian journal of physiology and pharmacology, 2010
Previous studies showed that amantadine transport increased while tetraethylammonium (TEA) transport decreased in kidney tissue from diabetic rats. Changes in transport activity were reversed by exogenous insulin. We hypothesized that this difference in transport regulation is due to differential regulation of different transport systems.
Alexander M, Gerlyand, Daniel S, Sitar
openaire   +1 more source

Renal vectorial transport of berberine mediated by organic cation transporter 2 (OCT2) and multidrug and toxin extrusion proteins 1 (MATE1) in rats

Biopharmaceutics & Drug Disposition, 2017
AbstractBerberine, a well‐known plant alkaloid derived from Rhizoma coptidis, has potential applications as a therapeutic drug for diabetic nephropathy. However, the transporter‐mediated renal transport of berberine remains largely unclear. This study aimed to investigate the renal transport mechanism of berberine using transfected cells, kidney slices
Rong Shi, Yuanyuan Yang, Zhangyao Xu, Yan Dai, Min Zheng, Tianming Wang, Yuanyuan Li, Yueming Ma   +7 more
openaire   +2 more sources