Results 111 to 120 of about 4,337,927 (386)

To robotize chemistry laboratories. An example of organic synthesis: 2‐Boc‐amino‐N‐hydroxy‐3‐phenyl‐propionamide [PDF]

, 2002
G. Christophe, L. Chapelant, Stéphane Bostyn, C. Porte, Alain Delacroix, Hugues d'Orchymont   +5 more
openalex   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Tailored novel phosphonate-based hybrid materials by design for diverse applications [PDF]

, 2018
Hybrid materials are composed of an organic and an inorganic part, placed together in such a way that the final product has defined structures and properties.
Demadis, Konstantinos D.
core  

Students’ & Faculty Members’ Attitudes Towards Learning and Teaching Reaction Mechanisms in Organic Chemistry

Education Sciences
Organic Chemistry has typically been identified as a difficult course for many undergraduate students and has a notoriously high failure rate. The part of the subject dealing with reaction mechanisms is considered the most challenging area, and several ...
Oluwatobi Odeleye, Nghiem Tieu
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

The cometary composition of a protoplanetary disk as revealed by complex cyanides

, 2015
Observations of comets and asteroids show that the Solar Nebula that spawned our planetary system was rich in water and organic molecules. Bombardment brought these organics to the young Earth's surface, seeding its early chemistry.
A Dutrey, A Dutrey, C Brinch, C Favre, C Qi, C Qi, C Qi, C Walsh, C Walsh, C Walsh, C Walsh, Chunhua Qi, D Lynden-Bell, D Semenov, David J. Wilner, DM Graninger, DP O’Brien, E Bergin, E Dartois, E Herbst, EC Fayolle, EF van Dishoeck, EF van Dishoeck, EI Chiang, FJ Ciesla, GM Muñoz Caro, H Nomura, JS Carr, K Furuya, K Tsiganis, KA Rosenfeld, Karin I. Öberg, Kenji Furuya, KI Öberg, KI Öberg, KI Öberg, KJ Walsh, KM Pontoppidan, L Hartmann, LI Cleeves, LI Cleeves, M Dubernet, M Simon, M Takami, M Wernli, MJ Mumma, MP Collings, MR Hogerheijde, N Goldman, N Sakai, P D'Alessio, P Gratier, P Hartogh, RT Garrod, Ryan Loomis, S Guilloteau, S Pizzarello, Sean M. Andrews, T Yamamoto, V Piétu, V Wakelam, Viviana V. Guzmán, Y Aikawa, Y Aikawa, Yuri Aikawa   +64 more
core   +1 more source

Notes on Organic Chemistry [PDF]

Science, 1906
J B, Tingle, F C, Blanck
openaire   +7 more sources

Physical Organic Chemistry in Latin America [PDF]

, 2008
E Hojo, Japan Osawa, Christian Reichardt, Wolffram Schröer, E. Tyihák, Alain Walcarius, V. O. Cheranovskiĭ, А. А. Дорошенко, O Gryzodub, Vitaly I. Kаlchеnkо, Г. Л. Камалов, А. И. Коробов, Lidia P. Loginova, А. Н. Попов, В. Н. Зайцев   +14 more
openalex   +1 more source