Results 91 to 100 of about 1,547,122 (263)

On the implications of aerosol liquid water and phase separation for modeled organic aerosol mass [PDF]

, 2016
Water is an important component of PM2.5 Many traditional SOA species are highly soluble and thus can be considered extractable Water can influence the partitioning of compounds traditionally considered insoluble in models Organic aerosol takes up water ...
Appel, KW, Budisulistiorini, SH, Carlton, AG, Goldstein, AH, Guo, H, Hu, W, Isaacman-Vanwertz, G, Jimenez, JL, Misztal, PK, Murphy, BN, Nenes, A, Ng, NL, Pye, HOT, Surratt, JD, Vasilakos, P, Weber, R, Xu, L   +16 more
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Synthesis and in Vitro Antitumor Activity of a Novel Series of 2-Pyrazoline Derivatives Bearing the 4-Aryloxy-7-chloroquinoline Fragment

Molecules, 2014
A new series of NH-pyrazoline derivatives 6 was synthesized by cyclocondensation reaction of novel [(7-chloroquinolin-4-yl)oxy]chalcones 5 with hydrazine hydrate.
Alba Montoya, Jairo Quiroga, Rodrigo Abonia, Manuel Nogueras, Justo Cobo, Braulio Insuasty   +5 more
doaj   +1 more source

A New Phytochemical Screening Programme used for Crops grown with Organic and Conventional Methods [PDF]

, 2002
A broad screening programme, covering the most general phytochemical groups of compounds, was developed on the basis of Thin Layer Chromatography (TLC).
Brandt, Kirsten, Christensen, Trine F., Diedrichsen, Brigitte, Kristensen, Charlotte V., Ravn, Dr. Helle Weber   +4 more
core  

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Efficient degradation of sulfamethoxazole using unactivated and biochar-activated peroxymonosulfate: Mechanisms and performance comparison

Water Cycle
Peroxymonosulfate (PMS)-based advanced oxidation processes are widely used in environmental purification. But the intrinsic oxidizing properties of unactivated PMS are often overlooked in pollutant degradation.
Xuhao Liu, Xiaoya Gao, Bingheng Liang, Qingcun Gu, Teng Guo, Jiatian Wang, Xingxin Yang   +6 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

The microbiome-derived antibacterial lugdunin acts as a cation ionophore in synergy with host peptides

mBio
Lugdunin is a microbiome-derived antibacterial agent with good activity against Gram-positive pathogens in vitro and in animal models of nose colonization and skin infection.
Anne Berscheid, Jan Straetener, Nadine A. Schilling, Dominik Ruppelt, Martin C. Konnerth, Birgit Schittek, Bernhard Krismer, Andreas Peschel, Claudia Steinem, Stephanie Grond, Heike Brötz-Oesterhelt   +10 more
doaj   +1 more source

Formation of reactive nitrogen species promoted by iron ions through the photochemistry of a neonicotinoid insecticide [PDF]

Atmospheric Chemistry and Physics
Nitrous acid (HONO) and nitrogen oxides (NOx=NO+NO2) are important atmospheric pollutants and key intermediates in the global nitrogen cycle, but their sources and formation mechanisms are still poorly understood.
Z. Ran, Z. Ran, Y. Hu, Y. Hu, Y. Hu, Y. Li, Y. Li, X. Gao, X. Gao, C. Ye, S. Li, X. Lu, Y. Luo, Y. Luo, Y. Luo, S. Gligorovski, S. Gligorovski, S. Gligorovski, J. Liu, J. Liu   +19 more
doaj   +1 more source