Results 1 to 10 of about 2,163 (177)

Photostability and Performance of Polystyrene Films Containing 1,2,4-Triazole-3-thiol Ring System Schiff Bases [PDF]

Molecules, 2016
Series of 4-(4-substituted benzylideneamino)-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazole-3-thiols were synthesized and their structures were confirmed. The synthesized Schiff bases were used as photostabilizers for polystyrene against photodegradation.
Ghassan Q Ali, Gamal A El-Hiti, Ivan Hameed R Tomi   +2 more
exaly   +6 more sources

Synthesis of 1,2,4-Triazole-3-Thiol Derivatives from Thiosemicarbazides and Carboxylic Acids Using Polyphosphate Ester [PDF]

Molecules
Conditions have been established for the direct reaction of thiosemicarbazides with carboxylic acids in the presence of polyphosphate ester (PPE) to synthesize 1,2,4-triazole-3-thiol derivatives.
Bogdan A. Tretyakov, Viktoria I. Tikhonova, Svyatoslav Y. Gadomsky, Nataliya A. Sanina   +3 more
doaj   +5 more sources

Pharmacological aspects of application of 1,2,4-triazole-3-thiol furan derivatives

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2016
Introduction. Nowadays 1,2,4-triazole-3-thiol furan derivatives have established themselves as a separate class of promising bioactive compounds. Presented substance is practically non-toxic and exhibits various kinds of pharmacological activity.
O. A. Bihdan, V. V. Parchenko, О. І. Panasenko, E. G. Knysh   +3 more
doaj   +4 more sources

Synthesis and analgesic activity of new pyrazole-containing derivatives of 1,2,4-triazole-3-thiol

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2023
Pain represents a primary symptom of numerous diseases and conditions, affecting millions of people worldwide. Effective analgesic medications can alleviate or eliminate pain, thereby enhancing patients’ quality of life and assisting them in resuming ...
S. O. Fedotov, A. S. Hotsulia, Yu. V. Karpenko   +2 more
doaj   +4 more sources

Novel 1,2,4-Triazole-Thiopyrimidine Hybrids as COX-2 Inhibitors: Synthesis, ADME Profiling, Antioxidant Activity, and Molecular Docking. [PDF]

Biomed Res Int
This work reports the design, synthesis, and multilevel evaluation of 20 new S‐alkyl derivatives of 6‐(5‐mercapto‐4‐ethyl‐4H‐1,2,4‐triazol‐3‐yl)pyrimidine‐2,4(1H,3H)‐dione as potential selective cyclooxygenase‐2 (COX‐2) inhibitors with antioxidant properties.
Karpenko Y, Parchenko V, Panasenko O, Bihdan O, Pukhalska I, Nikiforov O, Nahorna N, Nahornyi V, Roik O.   +8 more
europepmc   +2 more sources

Synthesis and Biological Properties of Novel Triazole-Thiol and Thiadiazole Derivatives of the 1,2,4-Triazole-3(5)-one Class

Molecules, 2014
2,2'-(4,4'(Butane-1,4-diyl/hexane-1,6-diyl)bis(3-methyl-5-oxo-4,5-dihydro-1,2,4- triazole-4,1-diyl)) diacetohydrazides 3a,b were obtained via the formation of diethyl 2,2'-(4,4'(butane-1,4-diyl/hexane-1,6-diyl)bis(3-methyl-5-oxo-4,5-dihydro-1,2,4 ...
Esra Dügdü, Yasemin Unver, Dilek Unluer   +2 more
exaly   +3 more sources

5-Furan-2yl[1,3,4]oxadiazole-2-thiol, 5-Furan-2yl-4H [1,2,4] triazole-3-thiol and Their Thiol-Thione Tautomerism

Molecules, 2005
5-Furan-2-yl[1,3,4]oxadiazole-2-thiol (Ia) and 5-furan-2-yl-4H-[1,2,4]-triazole-3-thiol (Ib) were synthesized from furan-2-carboxylic acid hydrazide. Mannich basesand methyl derivatives were then prepared.
Cetin A
exaly   +3 more sources

Synthesis and antimicrobial activity of s-substituted derivatives of 1,2,4-triazol-3-thiol

ScienceRise: Pharmaceutical Science, 2021
The aim of the work. 1,2,4-triazole derivatives possess a wide range of pharmacological activity, so they are used for the development of drugs and active pharmaceutical ingredients. Due to the reactivity of 1,2,4-triazoles there are many options for their further structural modification on different reaction centers. Therefore, the aim of the work was
Yevhen Karpun, Nataliia Polishchuk
openaire   +5 more sources

The synthesis of 4-amino-5-(quinolin-2-yl)-4H-1,2,4-triazole-3-thiol and its interaction with aldehydes

Журнал органічної та фармацевтичної хімії, 2021
Aim. To synthesize 4-amino-5-(quinolin-2-yl)-4H-1,2,4-triazole-3-thiol and study its reactivity in the reaction with aldehydes. Results and discussion.
D. М. Zozulynets, A. G. Kaplaushenko, A. S. Korzhova   +2 more
doaj   +1 more source

Search for antibacterial activity in a number of new S-derivatives (1,2,4-triazole-3(2H)-yl)methyl)thiopyrimidines

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2021
The relevance of the study of 1,2,4-triazole derivatives with pyrimidine fragment is due to the synthesis of potential broad-spectrum antibacterial drugs, low molecular weight inducers of interferon, and antitumor agents, search for molecular descriptors
Yu. V. Karpenko, O. I. Panasenko
doaj   +1 more source