Antiradical activity of novel 4-amino-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-3-thiol derivatives [PDF]
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2021 The process of studying free radicals began in the middle of the last century (the free radical theory of aging in 1956). Multiple studies have revealed the effect of free radicals on the cells of the body and the development of various diseases, such as
A. A. Safonov, I. S. Nosulenko
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Physical-chemical properties of 5-(3-fluorophenyl)-4-amino-1,2,4-triazole-3-thiol s-derivatives [PDF]
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2017 Introduction. Currently an attempt to combine 1,2,4-triazole heterocycle with various pharmacologically active fragments of other organic molecules is popular among the scientists.
O. A. Bihdan, V. V. Parchenko
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Study acute toxicity of 4-(R-amino)-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-3-thiol in vivo [PDF]
Фармацевтичний журнал, 2018 Typically, the system is already known are used as the core for a new substance, which have already proved themselves as potential drugs. So one of these is 1,2,4-triazole ring.
A. A. Safonov
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Antimicrobial activity of new 5-(furan-2-yl)-4-amino-1,2,4-triazole-3-thiol derivatives [PDF]
Zaporožskij Medicinskij Žurnal, 2017 The aim of this research was to investigate the antimicrobial activity of some new 5-(furan-2-yl)-4-amino-1,2,4-triazole-3-thiol substituents and in some cases to trace the relationship between activity of compounds and their structure.
D. M. Danilchenko, V. V. Parchenko
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Synthesis of Some New 4,5-Substituted-4H-1,2,4-triazole-3-thiol Derivatives [PDF]
Molecules, 2004 In this study appropriate hydrazide compounds, furan-2-carboxylic acidhydrazide (1) and phenylacetic acid hydrazide (2) were converted into 1,4-substitutedthiosemicarbazides 4a-e and 5a-e and 4-amino-5-(furan-2-yl or benzyl)-4H-1,2,4-triazole-3-thiols 7 and 10.
M. Koparır, A. Cansız, A. Demirdağ
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Synthesis, structure and properties of some 5-R-4-phenyl-1,2,4-triazole-3-thiol derivatives [PDF]
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2019 Pyrrole, 1,2,4-triazole and indole derivatives belong to the group of aza-heterocyclic compounds, which have been associated with significant advances in the development of new drugs.
A. S. Hotsulia
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Synthesis and properties of some pyrazole derivatives of 1,2,4-triazole-3-thiol [PDF]
Current issues in pharmacy and medicine: science and practice, 2020 Nitrogen-containing heterocyclic compounds play an important role in the modern pharmaceutical industry. This is due to their significant biological potential. 1,2,4-Triazole and pyrazole are known pharmacophores that are responsible for the formation of a wide range of activities.
Hotsulia, A. S., Kulish, S. M.
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Investigation of physical and chemical properties of new derivatives of 5-(thiophene-3-ylmethyl)-4R-1,2,4-triazole-3-thiols [PDF]
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2021 Heterocyclic compounds are one of the most important branches of modern organic chemistry and are widely used in medicine, pharmacy, agriculture, and in the production of new materials.
A. V. Khilkovets
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Theoretical Study of Tautomeric Conformations for 1,2,4-Triazole Derivatives [PDF]
Orbital: The Electronic Journal of Chemistry, 2021 We have performing theoretical calculations of the 1,2,4-triazole derivatives using DFT B3LYP method to study the tautomeric conformations of 1,2,4-triazole-3-thiol (TL 2A and TL 2C) and 1,2,4-triazole-3-thione (TL 2B) derivatives.
Radia Mahboub
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Anti-tuberculosis activity research of 5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-3-thiol [PDF]
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2019 Introduction. 1,2,4-Triazole derivatives have already proven themselves to be compounds with low toxicity and high antimicrobial, antifungal, antiviral, hepatoprotective activity.
A. A. Safonov, V. V. Zazharskyi
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