Results 1 to 10 of about 25,427 (164)

Novel 1, 2, 4-Triazoles as Antifungal Agents. [PDF]

Biomed Res Int, 2022
The development of innovative antifungal agents is essential. Some fungicidal agents are no longer effective due to resistance development, various side effects, and high toxicity. Therefore, the synthesis and development of some new antifungal agents are necessary. 1,2,4‐Triazole is one of the most essential pharmacophore systems between five‐membered
Kazeminejad Z, Marzi M, Shiroudi A, Kouhpayeh SA, Farjam M, Zarenezhad E.   +5 more
europepmc   +4 more sources

Synthesis, Antibacterial and Antifungal Activity of 4-Substituted-5-Aryl-1,2,4-Triazoles

Molecules, 2001
A few 4-allyl/amino-5-aryl-1,2,4-triazoles were synthesized and tested for antibacterial and antifungal effects against Escherichia coli, Bacillus subtilis, Salmonella enteritidis, Staphylococcus aureus, Aspergillus niger and Candida albicans.
Aleksandra Buzarovska, Dora Gabor Molnar, Vlado Kakurinov, Vesna Dimova, Katica Colanceska-Ragenovic   +4 more
doaj   +3 more sources

Torsade de Pointes/QT Prolongation Associated with Antifungal Triazoles: A Pharmacovigilance Study Based on the U.S. FDA Adverse Event Reporting System（FAERS）

Journal of Pharmacy & Pharmaceutical Sciences, 2022
Purpose: Torsade de pointes (TdP)/QT prolongation is a fatal adverse event (AE) when using antifungal triazoles. We aimed to compare the AE signals of TdP/QT prolongation and onset time among different drugs of this kind comprehensively.
Zicheng Yu, Xiaolan Liao
doaj   +1 more source

1,2,3-Triazole-4(5)-amines – Convenient Synthetic Blocks for the Construction of Triazolo-Annulated Heterocycles

Журнал органічної та фармацевтичної хімії, 2022
Aim. To analyze and summarize the synthetic potential of 1,2,3-triazole-4(5)-amines as efficient building blocks in the synthesis of triazolo-annulated pyridine, azine and azepine systems. Results and discussion.
Natalia O. Syrota, Sergiy V. Kemskiy, Lesya M. Saliyeva, Mykhailo V. Vovk   +3 more
doaj   +1 more source

Synthesis, antimicrobial and antifungal activity of 3-(2-bromophenyl)-5-(alkylthio)-4-phenyl-4H-1,2,4-triazoles

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2022
To select a molecule that could become a promising pharmacological agent, chemists use already-known heterocyclic bases by adding pharmacologically active groups. One such heterocyclic system is 1,2,4-triazole base, on the basis of which a huge number of
A. A. Safonov, O. I. Panasenko
doaj   +1 more source

Design and Synthesis of New 5-aryl-4-Arylethynyl-1H-1,2,3-triazoles with Valuable Photophysical and Biological Properties

Molecules, 2021
Cu-catalyzed 1,3-dipolar cycloaddition of methyl 2-azidoacetate to iodobuta-1,3-diynes and subsequent Suzuki-Miyaura cross-coupling were used to synthesize new triazoles derivatives: 5-aryl-4-arylethynyl-1H-1,2,3-triazoles. Investigation of their optical
Mariia M. Efremova, Anastasia I. Govdi, Valeria V. Frolova, Andrey M. Rumyantsev, Irina A. Balova   +4 more
doaj   +1 more source

Discovery of a new class of triazole based inhibitors of acetyl transferase KAT2A

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
We have recently developed a new synthetic methodology that provided both N-aryl-5-hydroxytriazoles and N-pyridine-4-alkyl triazoles. A selection of these products was carried through virtual screening towards targets that are contemporary and validated ...
Roberta Pacifico, Nunzio Del Gaudio, Guglielmo Bove, Lucia Altucci, Lydia Siragusa, Gabriele Cruciani, Menotti Ruvo, Rosa Bellavita, Paolo Grieco, Mauro F. A. Adamo   +9 more
doaj   +1 more source

Effects of 1, 2, 4-Triazole Additive on PEM Fuel Cell Conditioning [PDF]

Membranes, 2020
Melt processing is one of the essential technologies for the mass production of polymer electrolyte membranes (PEM) at low cost. Azoles have been widely used in PEM to improve their conductivity at a relatively low humidity and recently as bifunctional additives in a melt blowing processing for PEM mass production.
Zhao, Nana, Shi, Zhiqing, Chenitz, Régis, Girard, François, Mokrini, Asmae   +4 more
openaire   +4 more sources

Thermal Rearrangement of Allyl Substituted Unsymmetric 4H-1,2,4-Triazoles to the Corresponding 1H-1,2,4-triazoles

Molecules, 2001
A series of neat 4-(2-alkenyl) substituted 5-methyl-3-phenyl-4H-1,2,4-triazoles were thermolyzed at 320 oC producing a rearrangement products, of which the regioisomeric 1- and 2-substituted triazoles were the main products.
Per H.J. Carlsen, Ragnhild B. Olsen, KÃ¥re B. Jørgensen   +2 more
doaj   +1 more source

Regioselectivity in the Thermal Rearrangement of Unsymmetrical 4-Methyl-4H-1,2,4-triazoles to 1-Methyl-1H-1,2,4-triazoles

Molecules, 2001
The rearrangement of 4-methyl-3,5-diaryl-4H-1,2,4-triazoles to the corresponding 1-methyl-3,5-diaryl-1H-1,2,4-triazoles showed regioselectivity comparable to that observed for the alkylation of 3,5-diaryl-1H-1,2,4-triazoles.
Per H.J. Carlsen, Odd R. Gautun
doaj   +1 more source