Results 21 to 30 of about 25,693 (164)

Synthesis and structural features of 5-(4-(tert-butyl) phenyl)-4-((R)amino)-4H-1,2,4-triazole-3-thiols

open access: yesФармацевтичний журнал, 2018
Chemistry of heterocyclic compounds is one of the most popular sector in organic chemistry. Scientists allocate among them a class of derivatives of 1,2,4-triazole.
I. I. Aksyonova-Seliuk   +2 more
doaj   +1 more source

Syntheses of 1, 2, 4 Triazole Derivatives and their Biological Activity [PDF]

open access: yesJournal of Chemistry, 2007
Cyclisation of [4‐(4‐oxo‐2‐phenyl‐4H‐quinazolin‐3‐yl)‐phenoxy]‐acetic acid‐N′‐(substituted phenyl)‐thiosemicarbazides with sodium metal in 99.0 % ethanol gave 3‐[4‐(4‐substituted phenyl‐5‐thioxo‐4,5‐dihydro‐1H‐1,2,4 triazol‐3‐ylmethoxy)‐ phenyl]‐2‐phenyl‐3H‐quinazolin‐4‐one .
Freddy H. Havaldar, Abhay R. Patil
openaire   +2 more sources

Evaluation Of Antioxidant Activity Of 1, 2, 4-Triazole Derivatives With Morpholine Moiety

open access: yesHacettepe University Journal of the Faculty of Pharmacy, 2022
The aim of the work was to study the antioxidant activity of 4-R-3- (morpholinomethyl)-4H-1,2,4-triazole-5-thioles and their alkyl derivatives in vitro using the method of non-enzymatic initiation of lipid peroxidation. Among the 45 compounds studied, 8 showed varying degrees of AOA.
SHCHERBYNA, Roman   +5 more
openaire   +2 more sources

Synthesis, Evaluation and Characterization of Some 1,3,4-Triazole-2-one Derivatives as Antimicrobial Agents

open access: yesE-Journal of Chemistry, 2012
A series of novel compounds like 3[(phenyl substituted)-5-methyl-1(Benzosulphonylamine)]-1,3,4-triazole-2-ones II(a-f) were synthesized by treating 4-amino-1-phenyl-3-methyl-5-oxo-1,2,4-triazoles with benzene sulphonyl chloride using pyridine as solvent.
Mahabaleshwaraiah Neelgundmath   +1 more
doaj   +1 more source

SYNTHESIS AND ANTIBACTERIAL EVALUATION OF CERTAIN 1,2,4- TRIAZOLE AND THIAZOLID INONE DERIVATIVES

open access: yesZagazig Journal of Pharmaceutical Sciences, 1993
The synthesis of certain 3 - (4- chloro - 3,5 - đimethyl - phenoxy ) methyl 4-alkyl or aryl -5 mercapto - 1,2,4 - triazoles ( 5a - e) is described.
Awatef Farag   +3 more
doaj   +1 more source

Novel Syntheses of Some 1, 2, 4‐Triazoles as Potent Bacteriocidal Agents [PDF]

open access: yesJournal of Chemistry, 2009
A facile syntheses of 4‐aryl‐5‐(isomeric pyridoyl)‐3H‐1, 2, 4‐triazoles as potent bacteriocidal agents are described. The newly synthesized compounds were characterized by spectral and elemental analyses. Some compounds were screened for their antibacterial activity against S. aureus, E. coli, B. subtilis and P.aeruginosa. All compounds carrying 1, 2,
Ram Janam Singh, Dharmendra Kumar Singh
openaire   +2 more sources

Fast and Efficient Synthesis of Fluoro Phenyl 1,2,3-Triazoles via Click Chemistry with Ultrasound Irradiation and Their Biological Efficacy Against Candida albicans

open access: yesOrganics
Several fluoro phenyl triazoles were synthesized using click chemistry between fluoro phenyl azides and phenyl acetylene. Under ultrasound irradiation, this synthetic procedure was performed with Cu (I) in the presence of 1,10-phenanthroline.
Elisa Leyva   +3 more
doaj   +1 more source

Syntheses, Characterization and Biological Activity of Some 1, 2, 4‐Triazole Derivatives [PDF]

open access: yesJournal of Chemistry, 2009
Syntheses of a series of 3‐alkyl‐4‐ amino‐5‐ cyanomethyl‐4H‐1, 2, 4‐triazoles with active methylene groups are described. The newly synthesized compounds were characterized by spectral and elemental analyses. Some compounds were screened for their antibacterial activity against S. aureus, E. coli, B. subtilis and P. aeruginosa.
R. J. Singh, D. K. Singh
openaire   +2 more sources

Synthesis of New Bis-1,2,4-Triazole Derivatives

open access: yesMolecules, 2006
A series of new 1,2/1,3-bis[o-(N-methylidenamino-3-aryl-5-phenyl-4H-1,2,4-triazole-4-yl)phenoxy]ethane/propane derivatives 4 were prepared in good yields bytreatment of 4-amino-3-aryl-5-phenyl-4H-1,2,4-triazoles 2 with certain bis-aldehydes 1.Compounds 4
Hakan Bektas, Olcay Bekircan
doaj   +1 more source

The combined action of ERG11 gene overexpression and its mutations in the development of Candida albicans resistance to triazolic antifungals

open access: yesЖурнал микробиологии, эпидемиологии и иммунобиологии
Introduction. Modern medicine is faced with the resistance of Candida spp. to antimycotics, due to changes in the expression and structure of the ERG11 gene, the molecular target of triazoles.
Yuri V. Nesvizhsky   +9 more
doaj   +1 more source

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