Results 91 to 100 of about 57,488 (312)

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

ggClusterNet 2: An R package for microbial co‐occurrence networks and associated indicator correlation patterns

iMeta
Since its initial release in 2022, ggClusterNet has become a vital tool for microbiome research, enabling microbial co‐occurrence network analysis and visualization in over 300 studies.
Tao Wen, Yong‐Xin Liu, Lanlan Liu, Guoqing Niu, Zhexu Ding, Xinyang Teng, Jie Ma, Ying Liu, Shengdie Yang, Penghao Xie, Tianjiao Zhang, Lei Wang, Zhanyuan Lu, Qirong Shen, Jun Yuan   +14 more
doaj   +1 more source

Reduced Chemical Fertilizer Combined with Vermicompost Application Affects the Growth, Yield, and Quality of Watermelon

HortTechnology
Continuous application of chemical fertilizers in plant cultivation can lead to the deterioration of the soil environment, resulting in reduced crop yield and quality.
Dongying Hou, Dongtao Su, Kexing Hao
doaj   +1 more source

Endometrial Assembloid Model Reveals Endometrial Gland Development Regulation by Estradiol‐Driven WNT7B Suppression

Advanced Science, EarlyView.
This study developed a 3D endometrial assembloid model to study how uterine glands form and develop. They discovered key interactions between different cell types and identified WNT7B as a regulator controlled by estradiol‐mediated TGFβ1‐VDR interaction.
Xintong Li, Yanjie Guo, Jianlin Li, Yimeng Li, Leqian Lin, Hoi Kit Matthew Leung, Qingqing Zhang, Kai‐Fai Lee, Ka‐Wang Cheung, Ernest H. Y. Ng, William S. B. Yeung, Philip C. N. Chiu, Cheuk‐Lun Lee   +12 more
wiley   +1 more source

Analysis of the Growth of Mustard Green Plants (Brassica juncea L) with Liquid Organic Fertilizer (LOF) from Rice Waste Water

, 2023
Moez Amri, Erman Har, Ermi Husni
openalex   +1 more source

5‐Hydroxymethylcytosine Dynamics Reveals Coordinated Reprogramming of Parental Genomes and X Chromosome Dosage Balance in Mouse SCNT Embryos

Advanced Science, EarlyView.
Genome‐wide, high‐resolution profiling of hydroxymethylation in mouse SCNT embryos reveals a transient, allele‐symmetric 5hmC reprogramming pattern distinct from natural embryos, with X‐chromosomes and imprinting control regions resistant to proper remodeling.
Zeming Xiang, Rui Yan, Jing Guo, Mengyao Wang, Xin Cheng, Fan Zhang, Tianzi Guo, Xin Long, Fan Guo, Dan Liang   +9 more
wiley   +1 more source

Decoding Human Placental Cellular and Molecular Responses to Obesity and Fetal Growth

Advanced Science, EarlyView.
Women with obesity often deliver large‐for‐gestational‐age (LGA) infants. Single‐nucleus RNA sequencing of term placenta reveals that hypoxia and TNF‐α signaling in syncytiotrophoblasts are featured in maternal obesity, but inflammatory signatures in Hofbauer cells and response to lipid or carbohydrate metabolism in fibroblasts are specific to LGA.
Hong Jiang, Emilie Derisoud, Denise Parreira, Nayere Taebnia, Paulo R. Jannig, Reza Zandi Shafagh, Allan Zhao, Congru Li, Macarena Ortiz, Manuel Alejandro Maliqueo, Elisabet Stener‐Victorin, Volker M. Lauschke, Qiaolin Deng   +12 more
wiley   +1 more source

Wedelolactone, a Novel TLR2 Agonist, Promotes Neutrophil Differentiation and Ameliorates Neutropenia: A Multi‐Omics Approach to Unravel the Mechanism

Advanced Science, EarlyView.
Wedelolactone (WED), a natural TLR2 agonist, promotes neutrophil differentiation and enhances bactericidal function, offering a potential therapeutic strategy for neutropenia. Using a multi‐omics approach, this study reveals that WED activates the TLR2/MEK/ERK pathway, upregulating key transcription factors (PU.1, CEBPβ) to drive neutrophil development.
Long Wang, Zhichao Li, Tianci Hu, Qinyao Li, Linwei Zhang, Xinyue Mei, Xiao Qi, Sheng Liu, Weijie Kong, Jiesi Luo, Anguo Wu, Feihong Huang, Sirui Li, Shuang Dai, Chunxiang Zhang, Rong Li, Jianming Wu   +16 more
wiley   +1 more source

Effects of Biochar-Based Fertilizer on Root Zeta Potential, Nutrient Leaching and Yield in an Intensive Protected Cropping System

Land
Rising global demand for food and fibre requires more efficient and sustainable fertilizer strategies. Biochar mineral complexes (BMC) are being developed for use as an organic alternative to conventional synthetic fertilizers, or to supplement ...
Kane Trubenbacher, Shahla Hosseini Bai, Lakmini Dissanayake, Negar Omidvar, Stephen Joseph, Michael B. Farrar   +5 more
doaj   +1 more source

Growth and yield of edamame soybean in post-tin mining land with application of Rhizobium bacteria and organic fertilizer [PDF]

, 2021
Tri Lestari, Rion Apriyadi, Gitta Amandha   +2 more
openalex   +1 more source