Results 31 to 40 of about 602,894 (266)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Rural-urban transformation shapes oasis agriculture in Morocco’s High Atlas Mountains
Scientific ReportsTraditional agricultural activities and rural livelihoods in Morocco’s High Atlas Mountains are rapidly changing. This is triggered by increasing rural-urban interactions and new livelihood opportunities in cities.
Youness Boubou +2 more
doaj +1 more source
Telecoupled Resource Use: Roadside Woodfuel Trade in Urbanizing Benin
LandRapid urbanization and population growth in West Africa are intensifying pressure on natural resources and reconfiguring telecoupled supply chains, especially for essential household fuels like charcoal and firewood, here collectively referred to as ...
Youness Boubou +3 more
doaj +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Six Decades of Rural Landscape Transformation in Five Lebanese Villages
LandDuring the last six decades, Lebanon’s landscapes have undergone significant regime shifts whose causes are under-investigated. Using land cover maps from 1962 and satellite imagery from 2014 and 2023 in five randomly selected villages across Lebanon’s ...
Abed Al Kareem Yehya +4 more
doaj +1 more source
Food Flows and the Roles of Cities in West African Food Distribution Networks
Frontiers in Sustainable Food Systems, 2022 In West Africa, rampant urbanization is changing food systems, including the magnitude and composition of food flows and the length of supply chains. An increasing body of literature discusses pathways to sustainable transformation of urban food systems ...
Hanna Karg +7 more
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Environmental ChallengesQuarries are open pit mines, where construction materials such as granite and clay are extracted from the earth's surface, leading to a major disturbance of vegetation and subsequent degradation of ecosystem services.
Oussama Himmy +5 more
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source