Results 41 to 50 of about 9,376,044 (297)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Rural-urban transformation shapes oasis agriculture in Morocco’s High Atlas Mountains

Scientific Reports
Traditional agricultural activities and rural livelihoods in Morocco’s High Atlas Mountains are rapidly changing. This is triggered by increasing rural-urban interactions and new livelihood opportunities in cities.
Youness Boubou, Kira Fastner, Andreas Buerkert   +2 more
doaj   +1 more source

Telecoupled Resource Use: Roadside Woodfuel Trade in Urbanizing Benin

Land
Rapid urbanization and population growth in West Africa are intensifying pressure on natural resources and reconfiguring telecoupled supply chains, especially for essential household fuels like charcoal and firewood, here collectively referred to as ...
Youness Boubou, David Tonnan Amos Akankossi, Luc Hippolyte Dossa, Andreas Buerkert   +3 more
doaj   +1 more source

Importance of organic farming research in Sweden for innovations and increased sustainability in agriculture [PDF]

, 2013
Organic farming is known to be a knowledge intensive production system and there is a strong need for new knowledge and innovations to achieve increased sustainability.
Fredriksson, P., Nilsson, U., Röös, E., Gunnarsson, S., Wivstad, M., Johansson, B., Hoffman, R., Salomon, E., Sundberg, C., Ullvén, K., Mie, A., Wallenbeck, A.   +11 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Nitrogen Utilization in Integrated Crop and Animal Production [PDF]

, 2008
The principles of organic production are based on integration between crop and animal production and self-regulated nutrient intensity. A comparison between specialized dairy and crop farm models and an integrated dairy and crop farm model showed 24 ...
Seuri, Pentti, Seuri, P.
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Six Decades of Rural Landscape Transformation in Five Lebanese Villages

Land
During the last six decades, Lebanon’s landscapes have undergone significant regime shifts whose causes are under-investigated. Using land cover maps from 1962 and satellite imagery from 2014 and 2023 in five randomly selected villages across Lebanon’s ...
Abed Al Kareem Yehya, Thanh Thi Nguyen, Martin Wiehle, Rami Zurayk, Andreas Buerkert   +4 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source