Results 71 to 80 of about 73,168 (255)

Penggunaan Kromium Organik dari Beberapa Jenis Fungi terhadap Aktivitas Fermentasi Rumen Secara in Vitro

Media Peternakan, 2006
Chromium appears to be an essential trace element since 1959, but its effect on ruminal microbes is not clear yet. This experiment was conducted to study the effects of organic chromium supplementation on rumen fermentation activity.
W.D. Astuti, T. Sutardi, D. Evvyernie, T. Toharmat   +3 more
doaj  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Effect of organic chromium on the selected hematological profile of male Jawarandu goats under transportation stress

Jurnal Ilmu Peternakan Terapan
This study aimed to evaluate the effect of organic chromium supplementation on the physiological and hematological responses of male Jawarandu goats subjected to transportation stress.
Lusia Komala Widiastuti, Anggi Derma Tungga Dewi, Muhammad Mirandy Pratama Sirat, Ratna Ermawati   +3 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Effect of supplementation of organic minerals on the performance of broilers

The Indian Journal of Animal Sciences, 2013
Effect of supplementation of organic minerals on the performance of broilers was studied on 225 coloured synthetic broiler chicks randomly divided into 5 groups. The inorganic minerals viz. Zn, Cu and Mn were added @ 40, 8 and 60 ppm, respectively in control group (T1). The inorganic minerals of treatment group were replaced with organic minerals in T2
S K MISHRA, R K SWAIN, N C BEHURA, A DAS, A MISHRA, G SAHOO, A K DASH   +6 more
openaire   +1 more source

Organic selenium dietary supplementation improves pork meat stability during vacuum-packaged storage

Semina: Ciências Agrárias
This study assessed the effects of organic selenium supplementation in pig diets on meat quality and stability during refrigerated vacuum storage.
Marcela Maíra Miqueletto, Renata Ernlund Freitas de Macedo, Sthefany Kamile dos Santos, Leandro Batista Costa, Marcos Aronovich   +4 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Zinc intake ameliorates intestinal morphology and oxidative stress of broiler chickens under heat stress

Frontiers in Immunology
Zinc (Zn), an essential trace element for poultry, plays a crucial role in promoting growth, improving feed conversion efficiency, enhancing antioxidant activity, and preventing disease.
Ping Hu, Kaiqi Li, Xiaoxu Peng, Tongjia Yao, Chuyang Zhu, Haotian Gu, Hao-Yu Liu, Hao-Yu Liu, Ming-an Sun, Yun Hu, Wael Ennab, Wael Ennab, Xugang Luo, Demin Cai, Demin Cai   +14 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source