Donations of consumables and surgical instruments: how to ensure you really benefit
Advice on how to ensure that your unit benefits the most from donated medicines, medical consumables, and surgical instruments.
Ismael Cordero
doaj
Investigating transcription factor dynamics in health and disease using FRAP
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Kommunikation vid förändringsarbete. Hur kommunikation kring implementering av en statlig reform påverkat de anställdas benägenhet att acceptera förändring [PDF]
It is important for organizations to be able to adapt to change. By implementing new changes they are able to stay relevant and prosper. A critical factor when doing this is the ability to accurately communicate change to the employees. By doing so the
Selén, Johanna, Bertilsson, Nelly
core +1 more source
Administration in land management – the organisation and scope of new local bodies [PDF]
In the article the temporary organisation in land management and administration in 21 new communes is described, commented and critically analysed. Proposals for a rationalised system are given.
Breda Ogorelec
doaj
Background: New methods, means and approaches for increasing the efficiency of public administration are constantly being discovered. This paper considers the possibility of applying a new form of organisation-known as the process organisation structure ...
Salkić Ismet, Bošnjović Jasna
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Administration centrale. — Organisation du Secrétariat général
Bourbeau Olivier. Administration centrale. — Organisation du Secrétariat général. In: Bulletin administratif de l'instruction publique. Tome 12 n°223, 1869.
Bourbeau, Olivier
core +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source

