Results 231 to 240 of about 416,711 (288)

The impact of organisational change on employee commitment [PDF]

, 2014
Hudson, Jackie, Rumbles, Sally Diana
core   +1 more source

A Patient‐Derived Organ‐on‐Chip Platform for Modeling the Tumor Microenvironment and Drug Responses in Pancreatic Cancer

Advanced Science, EarlyView.
Researchers have developed a patient‐derived organ‐on‐a‐chip model for pancreatic cancer by integrating cancer cells with supportive stromal and immune cells inside a microfluidic device. This system mimics the tumor microenvironment, enabling personalized testing of chemotherapy and immunotherapy, and offering new insights into how targeting ...
Darbaz Adnan, Natan Roberto de Barros, Luca S. Santovito, Xuhong Cheng, Kristi M. Lawrence, Mariah K. Barnett, Martine D. Boetto, Neal Mehta, Ajaypal Singh, Lin Cheng, Xiangsheng Huang, Faraz Bishehsari   +11 more
wiley   +1 more source

Facilitators and Barriers of Relatives' Involvement in Care of Patients With Acquired Brain Injury or Malignant Brain Tumour: Scoping Review. [PDF]

Nurs Open
Guldager R, Sejr Smedegaard P, Nordentoft S, Aadal L, Ingerslev Loft M, Poulsen I.   +5 more
europepmc   +1 more source

Exclusive Breastfeeding Drives AMPK‐Dependent Thermogenic Memory in BAT and Promotes Long‐Term Metabolic Benefits in Offspring

Advanced Science, EarlyView.
Exclusive breastfeeding establishes a thermogenic memory in brown adipose tissue by activating the HIF1AN/AMPK/α‐ketoglutarate axis via milk‐derived extracellular vesicles enriched in miR‐125a‐5p. This programming preserves metabolic health, while αKG supplementation restores BAT function under mixed feeding, offering strategies to mitigate the ...
Ningxi Wu, Anwen Yin, Xiang Yu, Mingxin Wang, Jiahui Zhang, Kerong Liu, Yutong Hou, Minkai Cao, Yiting Zhang, Xiaoxiao Zhang, Yao Gao, Xirong Guo, Le Zhang, Yun Li   +13 more
wiley   +1 more source

Nurr1 Orchestrates Claustrum Development and Functionality

Advanced Science, EarlyView.
Nurr1 (Nr4a2) is the master transcription factor to control claustrum morphogenesis and cell fate decision postmitotically by inhibiting intracellular G‐protein signaling. Nurr1 deficiency alters the transcriptomic profiles of subcortical claustral neurons into neocortical insular neurons, resulting in defected claustrum development, impaired axonal ...
Kuo Yan, Andrew G. Newman, Pauline Lange, Susanne Müller, Marco Foddis, Stefan Paul Koch, Philipp Böhm‐Sturm, Maron Mantwill, Carsten Finke, Penghui Deng, Melissa Long, Dietmar Schmitz, Victor Tarabykin   +12 more
wiley   +1 more source

Beyond Capacity: Resilience of Intensive Care Staff During the COVID-19-Related Near-Disaster in Sweden. [PDF]

Nurs Crit Care
Nyberg PK, Günther M, Fagerdahl A, Älgå A.   +3 more
europepmc   +1 more source

Hyperviscous Diabetic Bone Marrow Niche Impairs BMSCs Osteogenesis via TRPV2‐Mediated Cytoskeletal‐Nuclear Mechanotransduction

Advanced Science, EarlyView.
Diabetic bone marrow exhibits pathological ECM hyperviscosity that activates TRPV2‐mediated Ca2⁺ influx, leading to perinuclear F‐actin disassembly, nuclear deformation, and chromatin condensation. This cytoskeletal‐nuclear decoupling suppresses osteogenic differentiation of BMSCs.
Yao Wen, Xinhui Zheng, Jieliu Li, Minyu He, Dongqi Fan, Xingyu Zhu, Qiming Zhai, Liangjing Xin, Tao Chen   +8 more
wiley   +1 more source

Experiences and support needs of psychiatrists under investigation. [PDF]

BJPsych Bull
Kongara S, Tamworth M, Gibbons R.
europepmc   +1 more source

Building an initial programme theory to explain how and why on-the-day surgery cancellations occur and how they might be reduced. [PDF]

BMC Health Serv Res
Samarasinghe BSW, Millar R, Exworthy M, Aunger J.   +3 more
europepmc   +1 more source

Exploring the Coordination of Cancer Care for Teenagers and Young Adults in England and Wales: BRIGHTLIGHT_2021 Rapid Qualitative Study. [PDF]

Cancers (Basel)
Bautista-Gonzalez E, Taylor RM, Fern LA, Barber JA, Cargill J, Dobrogowska R, Feltbower RG, Haddad L, Hall N, Lawal M, McCabe MG, Moniz S, Soanes L, Stark DP, Vindrola-Padros C.   +14 more
europepmc   +1 more source