Results 81 to 90 of about 446,896 (309)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Digital Transformation: The Impact of e-Commerce on Organisational Performance in Romanian Tourism and Accommodation SMEs [PDF]

Amfiteatru Economic
This study examines the impact of e-commerce adoption on multiple dimensions of performance of SMEs in the hospitality sector in Romania. Based on the updated version of the DeLone and McLean Model of IT Success in the Industry, the research defines ...
Alexandru Constăngioară, Olimpia Ban, Paul Ruge, Dorin-Cristian Coita, Naiana Țarcă , Adriana Mirela Constăngioară   +5 more
doaj   +1 more source

CONTROL – ESSENTIAL FACTOR OF ORGANISATIONAL PERFORMANCE [PDF]

An important feature of the people – organisation relationship is the need for control. Control systems exist in all spheres of the operations of the organisation and are necessary part of the process of management.
Luigi-Nicolae Dumitrescu
core  

Process performance measurement support : a critical analysis [PDF]

, 2001
Design development processes, within engineering disciplines, lack the necessary mechanisms in identifying the specific areas where improved design development performance may be obtained.
Duffy, Alex H. B., Haffey, Mark K. D.
core  

Influence of national culture and balanced organizational culture on the hotel industry's performance [PDF]

, 2017
This study investigates the role of national culture and balanced organisational culture in organisational performance. Hotel management requires flexibility and customer responsiveness to deal with increasingly demanding customers and competitiveness of
Atkinson, P., Atkinson, P., Foroudi, P., Foroudi, P., Nazarian, A., Nazarian, A.   +5 more
core   +4 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

On Factors explaining Organisational Innovation and its Effects [PDF]

This paper demonstrates how various factors influence the probability of attempts at organisational innovation and the effects of such innovation. An integrated firm-level dataset obtained from two recent waves of the Norwegian Community Innovation ...
Koson Sapprasert
core  

The role of corporate governance and boards in organisational performance

, 2010
For more than two decades, successive UK governments have been concerned with modernising the delivery of public services and seeking performance improvements.
Chambers, Naomi, Cornforth, Chris
core   +1 more source

Characteristics of High Performance Organisations [PDF]

Journal of Management Research, 2011
Because of the recent recession, interest into the factors that determine sustainable organisational success has increased. Managers all over the world are trying out various improvement concepts, seeing mixed results. One likely reason for this is the lack of consensus on the organisational characteristics that lead to high performance.
openaire   +3 more sources