Results 71 to 80 of about 7,126,451 (278)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Towards organisational simplexity — a simple structure in a complex environment
Engineering Management in Production and Services, 2019 The article contributes to the discussion on the validity and ways of simplifying modern organisations. There is an increasing focus on simplifying organisations, especially their organisational structures.
Tworek Katarzyna +2 more
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
DSpace-Konsortium Deutschland – konsortial die Nachhaltigkeit sichern
Library Ideas, 2019 DSpace ist eine Open-Source-Software, auf der weltweit circa 45% der Open-Access-Repositorien basieren (Quelle: opendoar.org, 15.10.2019). Im Jahr 2018 gründeten 25 akademische Institutionen in Deutschland das DSpace-Konsortium Deutschland mit dem Ziel ...
Beate Rajski, Pascal Becker
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Exploring the organisational structure of networks for exercise oncology provision: a social network analysis of OnkoAktiv. [PDF]
BMC Health Serv Res, 2023 Voland A +4 more
europepmc +1 more source
Support, Bedarfserhebung, Wissensvermittlung: Der DARIAH-DE Helpdesk
Library Ideas, 2019 Die Nachhaltigkeit einer digitalen Forschungsinfrastruktur hängt nicht nur von Technik, sondern vor allem von dem Vertrauen ihrer NutzerInnen ab. Dieses Vertrauen wiederum resultiert insbesondere aus dem erkennbaren Mehrwert, den die Angebote der ...
Andrea Bertino, Jan Rohden
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source