Results 101 to 110 of about 395,535 (315)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Integrating on-line learning technologies into higher education [PDF]

, 2004
This dissertation presents an in-depth, qualitative case study that documents the efforts of two UK universities to integrate on-line learning technologies into their teaching practices and course design.
Darking, Mary
core  

Leeway for the loyal: a model of employee discretion [PDF]

, 2008
This article examines the factors underlying task discretion from an economist's perspective. It argues that the key axis for understanding discretion is the trade-off between the positive effects of discretion on potential output per employee and the ...
Allen N. J., Athey S., Braverman H., Bryson A., Cooper R., Davis L. E., Department of Trade and Industry. Employment Markets Analysis and Research, European Foundation for the Improvement of Living and Working Conditions, Felstead A., Felstead A., Lehto A.-M., Lehto A.-M., Leiulfsrud H., Lincoln J. R., Millward N., Mowday R. T., Peters T., Piore P., Taylor M. P., Theorell T., Vogel J., Walton R. E.   +21 more
core   +3 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Dynamics of performance measurement and organizational culture [PDF]

, 2006
This research paper aims to model the dynamic relationship between performance measurement, management styles and organisational culture, in order to develop a better understanding of the causal linkages between these three ...
Bititci, Umit, Garengo, Patrizia, Mendibil, Kepa, Nudurupati, Sai, Turner, Trevor   +4 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

ASPECTS OF ORGANISATIONAL CULTURE AND CHANGE MANAGEMENT [PDF]

Annals of the University of Petrosani: Economics, 2018
Effective adaptation of organisations regarding the competitive environment involves undergoing a process of important changes which must take into account the organisational culture, which is an essential component of an organisation’s transformation ...
ELENA-IZABELA POPA
doaj  

The ethical infrastructure of legal practice in larger law firms: values, policy and behaviour [PDF]

, 2008
The article examines the impact of the cultures and organisational structures of large law firms on individual lawyers' ethics. The paper suggests that large law firms in Australia should consciously design and implement 'ethical infrastructures' to both
Evans, Adrian, Haller, Linda, Le Mire, Suzanne, Mortensen, Reid, Parker, Christine   +4 more
core  

Transformational Leadership: Building an Effective Culture to Manage Organisational Knowledge [PDF]

, 2017
This paper reviews the current literature of management to indicate how transformational leaders contribute to organisational knowledge by building an effective culture.
Ghasabeh, Mostafa Sayyadi, Provitera, Michael J.   +1 more
core   +2 more sources